产品描述(Product Details)
The Ready-to-use liver organoids are derived form human iPS cells and being cultured for more than 60 days. Organoids generated using Human iPSC-Derived liver organoid feature various types of cells, including hepatocytes, bile duct cells and vascular endothelial cells.
产品特征(Product Specification)
The live organoids are ready-to-use organoids that are delivered in shipping medium and has to go through a 48h recovery process according to instruction.
存储(Storage)
After recovery, please store the organoid in its maintenance medium under the correct incubation condition and medium changing process.
产品示意(Product Diagram)
Protocol Diagram of liver organoid differentiation.
验证数据(Validation Data)
Orgnaoid Histology
H&E Staining of liver organoid.
Marker Expression
The liver organoids show expression of hepatocytes (HNF4a), hepatobiliary tracts (CK19), Albumin (ALB) and vascular endothelial cell (CD31).
Pre-mature liver organoids show liver lobules-like structure.
Organoid Activity
Liver organoids show better performance than HepG2 cell line in terms of the expression of Albumin, CYP3A4, CYP1A2, CYP2C9, CYP7A1 and BSEP.
Liver organoid show response to Rifampicin treatment as indication by the increase fluorescence intensity of CYP3A4.