分子别名(Synonym)
latent GDF-8, GDF-8, Myostatin, GDF8, MSTN, Growth,differentiation factor 8
表达区间及表达系统(Source)
Human Latent GDF-8 Protein, His Tag (GD8-H5343) is expressed from CHO cells. It contains AA Asn 24 - Ser 375 (Accession # O14793-1).
Predicted N-terminus: Asn 24
蛋白结构(Molecular Characterization)
This protein carries a polyhistidine tag at the N-terminus.
The protein has a calculated MW of 42.0 kDa.
制剂(Formulation)
Please contact us for detailed information.
Contact us for customized product form or formulation.
重构方法(Reconstitution)
Please see Certificate of Analysis for specific instructions.
For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.
存储(Storage)
For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Please avoid repeated freeze-thaw cycles.
This product is stable after storage at:
- -20°C to -70°C for 12 months in lyophilized state;
- -70°C for 3 months under sterile conditions after reconstitution.
背景(Background)
Growth differentiation factor 8 (GDF8), also known as myostatin, is a unique member of the transforming growth factor-β superfamily that is expressed in human granulosa cells and has important roles in regulating a variety of ovarian functions. GDF8 acts as a negative regulator of skeletal muscle growth and differentiation. In addition to the expression in the musculoskeletal system, GDF8 is also expressed in various tissues, including the reproductive system.