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 >  Protein>Activin RIIB >ACB-H5254

Human Activin RIIB Protein, Fc Tag (MALS verified)

分子别名(Synonym)

ACVR2B,ACTRIIB,MGC116908

表达区间及表达系统(Source)

Human Activin RIIB Protein, Fc Tag (ACB-H5254) is expressed from human 293 cells (HEK293). It contains AA Ser 19 - Thr 137 (Accession # Q13705-1 ).

Predicted N-terminus: Ser 19

Request for sequence

蛋白结构(Molecular Characterization)

Activin RIIB Structure

This protein carries a human IgG1 Fc tag at the C-terminus.

The protein has a calculated MW of 40.1 kDa. The protein migrates as 55-65 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

>90% as determined by SEC-MALS.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

Activin RIIB SDS-PAGE

Human Activin RIIB Protein, Fc Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90% (With Star Ribbon Pre-stained Protein Marker).

SEC-MALS

Activin RIIB SEC-MALS

The purity of Human Activin RIIB Protein, Fc Tag (Cat. No. ACB-H5254) is more than 90% and the molecular weight of this protein is around 95-115 kDa verified by SEC-MALS.

Report

 

活性(Bioactivity)-ELISA

Activin RIIB ELISA

Immobilized Human Latent Activin A, His Tag (Cat. No. ACA-H424x) at 5 μg/mL (100 μL/well) can bind Human Activin RIIB Protein, Fc Tag (Cat. No. ACB-H5254) with a linear range of 0.6-20 ng/mL (QC tested).

Protocol

 

背景(Background)

Activin receptor type-2B (ACVR2B) is also known as ActR-IIB and MGC116908, ACVR2B is an activin type 2 receptor. Activins are dimeric growth and differentiation factors which belong to the transforming growth factor-beta (TGF-beta) superfamily of structur.

 

前沿进展

 
 
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Activin RIIB靶点信息
英文全称:Activin receptor type-2B
中文全称:激活素受体-2B
种类:Homo sapiens
上市药物数量:0详情
临床药物数量:2详情
最高研发阶段:临床二期
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