膜杰作
Star Staining
产品描述（Product Details）
Human iPSC-Derived Midbrain Organoids are generated from iPSCs using the Human iPSC-Derived Cerebral Organoid Differentiation Kit. These 3D in vitro models replicate the midbrain's cellular composition, showing high expression of the dopaminergic neuron marker TH and dopaminergic progenitor cells marker FOXA2 and OTX2. In addition, midbrian organoid exhibit functional characteristics such as spontaneous neuronal activity, making them ideal for studying neurological Parkinson's diseases and for drug screening applications.
产品特征（Product Specification）
The midbrain organoid are ready-to-use organoids that are delivered in shipping medium and has to go through a 48h recovery process according to instruction.
存储（Storage）
After recovery, please store the organoid in its maintenance medium under the correct incubation condition and medium changing process.
产品示意（Product Diagram）
Protocol Diagram of midbrain organoid differentiation.
验证数据（Validation Data）
Marker Expression
The midbrain organoids exhibit high expression of TH (dopaminergic neurons), MAP2 (mature neurons), as well as FOXA2 and OTX2 (dopaminergic progenitor cells) on day 37.
Organoid Activity
On day 37, midbrain organoids show significantly higher expression of TH and FOXA2 compared to cerebral organoids (Ca. No. CIPO-BWL001K).
Organoid Application
L-dopa causes midbrain organoids to turn black due to dopamine synthesis and subsequent oxidation into dark pigments.
