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 >  Antibody>CD4 >FABm002-04

PE-CY7-Labeled Monoclonal Anti-Human CD4 Antibody, Mouse IgG1 (8C3)

抗体来源(Source)

Monoclonal Anti-Human CD4 Antibody, Mouse IgG1 (8C3) is a mouse monoclonal antibody produced from hybridoma.

应用(Application)

Flow Cytometry (Evaluation of the expression of CD4 on Human cells).

种属(Species)

Mouse

亚型(Isotype)

Mouse IgG1 | Mouse kappa

特异性(Specificity)

This product is a specific antibody specifically reacts with CD4 protein.

种属反应性(Reactivity)

Human

免疫原(Immunogen)

Purified Human CD4 Protein.

偶联(Conjugate)

PE-CY7

Excitation Wavelength: 561 nm

Emission Wavelength: 780 nm

推荐稀释比(Recommended Dilution)

1:20

制剂(Formulation)

Supplied as 0.2 μm filtered solution in PBS, 0.2% BSA, 0.03% Proclin 300, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

存储(Storage)

Please protect from light and avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. Store at 2-8 °C for 12 months.
 

活性(Bioactivity)-FACS

CD4 FACS

Flow cytometric analysis of Human peripheral blood lymphocytes respectively staining with PE-CY7-Labeled Anti-Human CD4 Antibody Mouse IgG1(Cat. No. FABm002-01) at 1:20 dilution (5 μL of the antibody stock solution corresponds to labeling of 2.5e5 cells in a final volume of 100 µL), compared with isotype control antibody. PE-CY7 signal was used to evaluate the binding activity (QC tested).

Protocol

 

背景(Background)

T-cell surface glycoprotein CD4 is also known as T-cell surface antigen T4/Leu-3. CD4 contains three Ig-like C2-type (immunoglobulin-like) domains and one Ig-like V-type (immunoglobulin-like) domain. CD4 is accessory protein for MHC class-II antigen/T-cell receptor interaction. CD4 induces the aggregation of lipid rafts. CD4 is a primary receptor used by HIV-1 to gain entry into host T cells. HIV infection leads to a progressive reduction of the number of T cells possessing CD4 receptors. Therefore, medical professionals refer to the CD4 count to decide when to begin treatment for HIV-infected patients.

 

前沿进展

 
 
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CD4靶点信息
英文全称:T-cell surface antigen CD4
中文全称:T细胞表面抗原CD4
种类:Homo sapiens
上市药物数量:1详情
临床药物数量:23详情
最高研发阶段:批准上市
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