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 >  Protein>IFN-gamma R1 >IF1-H5223

Human IFN-gamma R1 / IFNGR1 Protein, His Tag

分子别名(Synonym)

IFNGR1,CD119,CDw119,IFNGR,IFN-gamma-R1

表达区间及表达系统(Source)

Human IFN-gamma R1, His Tag (IF1-H5223) is expressed from human 293 cells (HEK293). It contains AA Glu 18 - Gly 245 (Accession # AAH05333).

Predicted N-terminus: Glu 18

Request for sequence

蛋白结构(Molecular Characterization)

IFN-gamma R1 Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 26.6 kDa. The protein migrates as 35-45 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>95% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

IFN-gamma R1 SDS-PAGE

Human IFN-gamma R1, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 95%.

 

活性(Bioactivity)-ELISA

IFN-gamma R1 ELISA

Immobilized Human IFN-gamma, premium grade (Cat. No. IFG-H4211) at 5 μg/mL (100 μL/well) can bind Human IFN-gamma R1, His Tag (Cat. No. IF1-H5223) with a linear range of 0.01-0.313 μg/mL (Routinely tested).

Protocol

 

背景(Background)

Interferon gamma receptor 1 (IFNGR1) is also known as CD antigen CD119, which belongs to the type II cytokine receptor family. IFNGR1 contains two fibronectin type-III domains and two Ig-like C2-type (immunoglobulin-like) domains. IFNGR1 / CD119 is receptor for interferon gamma. Two receptors bind one interferon gamma (IFNG) dimer.

 

前沿进展

 
 
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IFN-gamma R1靶点信息
英文全称:Interferon gamma receptor
中文全称:干扰素γ受体复合体
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上市药物数量:11详情
临床药物数量:2详情
最高研发阶段:批准上市
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