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 > 【Alpha-Synuclein】

Alpha-Synuclein信息

英文名称：Synuclein alpha
中文名称：α-突触核蛋白
靶点别称：Truncated Alpha Synuclein，Α-Synuclein，Non-A Beta Component Of AD Amyloid，Synuclein Alpha-140，I+/--Synuclein，α-Synuclein，PARK4，PD1，alpha-Synuclein，Synuclein， Alpha (Non A4 Component Of Amyloid Precursor)，Non A-Beta Component Of AD Amyloid，PARK1，SNCA，Synuclein Alpha，NACP，Parkinson Disease (Autosomal Dominant， Lewy Body) 4，Non-A4 Component Of Amyloid Precursor，Non A4 Component Of Amyloid Precursor
上市药物数量：0
临床药物数量：23
最高研发阶段：临床三期

Alpha-Synuclein产品列表

筛选结果
产品库
物种
标签
属性
标记
货号 物种 产品描述 蛋白结构 纯度 活性
ALN-H5214
Human		 Human Alpha-Synuclein Protein, Tag Free (MALS verified)
ALN-H52H8
Human		 Human Alpha-Synuclein Protein, His Tag
ALN-H5115
Human		 Human Alpha-Synuclein Pre-formed Fibrils Protein, Tag Free
ALN-H82H8
Human		 Biotinylated Human Alpha-Synuclein Protein, His,Avitag™
ALN-H5253
Human		 Human Alpha-Synuclein Protein, Fc Tag (MALS verified)
CHEK-ATP085
Human		 HEK293/Human Alpha-synuclein (GFP) Stable Cell Line
ALN-C52H5
Cynomolgus		 Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
ALN-H5114
Human		 Human Alpha-Synuclein (A53T) Pre-formed Fibrils Protein, Tag Free
ALN-H5116
Human		 Human Alpha-Synuclein (A53T) Protein, Tag Free, low endotoxin (MALS verified)
ALN-H5117
Human		 Human Alpha-Synuclein (E46K) Protein, Tag Free (MALS verified)
ALN-H51H5
Human		 Human Alpha-Synuclein (A53T) Protein, His Tag (MALS verified)
ALN-HA113
Human		 Alexa Fluor™ 488-Labeled Human Alpha-synuclein Protein, Tag Free
ALN-M52H6
Mouse		 Mouse Alpha-Synuclein Protein, His Tag, low endotoxin (MALS verified)
ACRO质量管理体系
 
评论(1)
ALN-C52H5|Cynomolgus Alpha-Synuclein Protein, His Tag (MALS verified)
  1. 136XXXXXXX5
    2. 6人赞
  2. 老顾客了 希望能一直保持好质量 每次实验都能得到很好的结果 核蛋白活性数据很好 纯度也很让我们满意 做实验首选我们会继续选这家
  3. 2022-08-17
 

Alpha-Synuclein分子别名

SNCA,NACP,PARK1,alpha-Synuclein

Alpha-Synuclein分子背景

Alpha-synuclein is a neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. It acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. Abnormalities in alpha-synuclein are implicated in the pathogenesis of Parkinson's disease (PD). Alpha-synuclein is present in Lewy-bodies, the neuropathological hallmark of PD, and the protein and its aggregation have been widely linked to neurotoxic pathways that ultimately lead to neurodegeneration.

Alpha-Synuclein临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Buntanetap ANVS-405; ANVS-401 临床三期 Raptor Pharmaceutical 唐氏综合征, 慢性创伤性脑病, 阿尔茨海默病, 帕金森病, 轻度认知障碍, 额颞痴呆 详情
Lu AF-82422 (Lundbeck A/S) Lu AF-82422; Lu AF82422; Lu-AF82422 临床三期 灵北制药, Genmab A/S 帕金森病, 多系统萎缩 详情
MEDI-1341 MEDI-1341; TAK- 341 临床二期 阿斯利康, Takeda Pharmaceutical Co Ltd 帕金森病, 多系统萎缩 详情
Prasinezumab PRX-002; RG-7935; NEOD-002; RO-7046015 临床二期 Prothena 帕金森病 详情
Kenterin ENT-01; kenterin; Enterin-01 临床二期 Enterin Inc 便秘, 帕金森病, 痴呆 详情
UB-312 UB-312 临床二期 United Neuroscience Ltd 帕金森综合征, 帕金森病, 多系统萎缩 详情
PBT-434 PBT-434; ATH-434 临床二期 Prana Biotechnology Ltd 多系统萎缩 详情
MT101-5 MT101-5 临床二期 Mthera Pharma Co Ltd 帕金森病 详情
AMDX-2011P AMDX2011P; AMDX-2011P 临床二期 Amydis Inc 脑淀粉样血管病, 开角型青光眼, 帕金森病, 阿尔茨海默病, 肌萎缩性侧索硬化 详情
ACI-7104 ACI-7104.056; ACI-7104 临床二期 Ac Immune Sa 帕金森病 详情
Minzasolmin UCB-1332; NPT200-11; DLX-313; DLX313; UCB-0599 临床二期 Neuropore Therapies Inc 帕金森病 详情
Exidavnemab PD-0805; BAN-0805; BBV-0805; ABBV-0805; PR-1808164 临床二期 Bioarctic Ab 帕金森病 详情
Emrusolmin TEV-56286; TEV-'286; TEV-286; Anle-138b 临床二期 Ludwig-Maximilians-University, 马克斯·普朗克生物物理化学研究所 帕金森病, 多系统萎缩 详情
ION-464 BIIB-101; IONIS-BIIB6 Rx; ION-464 临床一期 Ionis Pharmaceuticals Inc 多系统萎缩 详情
SAR-446159 ABL-301; SAR-446159 临床一期 Abl Bio Inc 帕金森病 详情
AB-16 AB-16 临床一期 Autotac Bio Inc 帕金森病 详情
ACI-12589 ACI-12589; a-syn-PET tracer (AC Immune); [18F]MNI-1216; [18F]ACI-12589 临床一期 Ac Immune Sa, 百健, Invicro Llc 共核蛋白病, 帕金森病, 路易氏体型失智症, 多系统萎缩 详情
PK-081 PK081; PK-081 临床一期 PharmaKure Ltd 帕金森病 详情
SNP201 SNP201; SNP-201 临床一期 SciNeuro Pharmaceuticals 帕金森病 详情
[18F]UCB-2897 临床一期 Invicro Llc 帕金森综合征, 帕金森病, 多系统萎缩 详情
ACI-3847 ACI-3847; 18F-ACI-3847 临床一期 Ac Immune Sa, 百健 帕金森病, 神经变性疾病 详情
UCB-7853 UCB-7853 临床一期 Ucb Biopharma Srl 帕金森病 详情
Syneuro (Indus Biotech) 临床阶段不明 Indus Biotech Pvt Ltd 帕金森病 详情

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