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Tyk2信息

英文名称:Tyrosine-protein kinase 2
中文名称:酪氨酸蛋白激酶TYK2
靶点别称
上市药物数量:1
临床药物数量:8
最高研发阶段:批准上市

Tyk2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
TY2-H5547
Human
Human Tyk2 Protein, His Tag (active enzyme)
TY2-H5548
Human
Human Tyk2 Protein, His Tag
ACRO质量管理体系
 
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Tyk2分子别名

Tyk2,tyrosine kinase 2

Tyk2分子背景

Tyk2 was the first member of the JAK family that was described (the other members are JAK1, JAK2, and JAK3). It has been implicated in IFN-α, IL-6, IL-10 and IL-12 signaling. Tyk2 functions primarily in IL-12 and type I-IFN signaling. Tyk2 deficiency has more dramatic effects in human cells than in mouse cells. However, in addition to IFN-α and -β and IL-12 signaling, Tyk2 has major effects on the transduction of IL-23, IL-10, and IL-6 signals. Recently, it has been recognized that IL-12 and IL-23 share ligand and receptor subunits that activate Tyk2. Tyk2 is activated by IL-10, and its deficiency affects the ability to generate and respond to IL-10.

Tyk2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验

Tyk2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验

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