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Fas Ligand信息

英文名称:Soluble Fas ligand
中文名称:可溶性Fas配体
靶点别称:CD95L,Fas ligand,SPA,FASLG,Soluble Fas ligand,sFasL,Receptor-binding FasL ectodomain,FasL ICD,TNFSF6,Apoptosis antigen ligand,Tumor necrosis factor ligand superfamily member 6,APL,CD178,Fas Ligand (TNF Superfamily, Member 6),Fas Antigen Ligand,CD95 Ligand,CD95-L,APTL,Mutant Tumor Necrosis Factor Family Member 6,Apoptosis (APO-1) Antigen Ligand 1,CD178 Antigen,ALPS1B,TNLG1A,FasL,Fas Ligand Protein,SPPL2A-processed FasL form,APT1LG1,Tumor Necrosis Factor (Ligand) Superfamily, Member 6,Tumor Necros
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Fas Ligand产品列表

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Fas Ligand分子别名

FASLG,ALPS1B,APT1LG1,CD178,CD95L,FASL,TNFSF6

Fas Ligand分子背景

Fas ligand is also known as FasL, CD178, CD95L, or TNFSF6, is a homotrimeric type-II transmembrane protein that belongs to the tumor necrosis factor (TNF) family. Its binding with its receptor induces apoptosis. Fas ligand/receptor interactions play an important role in the regulation of the immune system and the progression of cancer. Mature human Fas Ligand consists of a 179 amino acid (aa) extracellular domain (ECD), a 22 aa transmembrane segment, and a 80 aa cytoplasmic domain. Within the ECD, human Fas Ligand shares 81% and 78% aa sequence identity with mouse and rat Fas Ligand, respectively. Apoptosis triggered by Fas-Fas ligand binding plays a fundamental role in the regulation of the immune system. Its functions include:T-cell homeostasis, cytotoxic T-cell activity, immune privilege, maternal tolerance, tumor counterattack. Defective Fas-mediated apoptosis may lead to oncogenesis as well as drug resistance in existing tumors. Germline mutation of Fas is associated with autoimmune lymphoproliferative syndrome (ALPS), a childhood disorder of apoptosis.

Fas Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Asunercept CAN-008; APG-101 临床二期 Apogenix Gmbh 胶质母细胞瘤, 骨髓增生异常综合征, 新型冠状病毒感染 详情

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