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KRAS信息

英文名称:V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
中文名称:V-Ki-ras2 Kirsten大鼠肉瘤病毒癌基因同源蛋白
靶点别称:KRAS,V-Ki-ras2 Kirsten rat sarcoma viral oncogene homolog
上市药物数量:0
临床药物数量:17
最高研发阶段:临床二期

KRAS分子别名

GTPase Kras,K-Ras 2,Ki-Ras,c-K-ras,c-Ki-ras,KRAS2,RASK2,C-K-RAS,CFC2,K-RAS2A,K-RAS2B,K-RAS4A,K-RAS4B,KI-RAS,KRAS1,KRAS2,NS,NS3,RASK2,KRAS

KRAS分子背景

KRAS (Kirsten rat sarcoma 2 viral oncogene homolog) gene is a proto-oncogene that encodes a small GTPase transductor protein called KRAS. KRAS is also known as Ki-Ras, c-K-ras and c-Ki-ras. Ras proteins bind GDP/GTP and possess intrinsic GTPase activity. Plays an important role in the regulation of cell proliferation, promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner. RAS is one of the most frequently mutated oncogenes in human cancer but the frequency and distribution of RAS gene mutations are not uniform. In details, mutation of glycine 12 (G12) causes RAS activation by interfering with GAP binding and GAP-stimulated GTP hydrolysis. The reference shows the pathway may as a potential therapy targets.

KRAS临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
ZG-2001 ZG2001; ZG-2001 临床二期 苏州泽璟生物制药股份有限公司 实体瘤, 肿瘤 详情
ELI-002 Amph-CpG-7909; ELI-002; ELI-002 2P; VED-002 临床二期 Elicio Therapeutics 卵巢癌, 实体瘤, 残余肿瘤, 胆管上皮癌, 结直肠癌, 胆道癌, 胆囊癌, 胰腺导管癌, 非小细胞肺癌 详情
Pooled mutant-KRAS peptide vaccine (Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins) 临床一期 Sidney Kimmel Comprehensive Cancer Center 胰腺癌, 结直肠癌, 非小细胞肺癌 详情
mRNA-5671 mRNA-5671 临床一期 Moderna Inc, Merck & Co Inc 胰腺癌, 肿瘤, 结直肠癌, 非小细胞肺癌 详情
mDC3/8-KRAS Vaccine (University of Pennsylvania) 临床一期 宾夕法尼亚大学 胰腺导管癌 详情
BI-3706674 BI-3706674; BI3706674; BI 3706674 临床一期 勃林格殷格翰 实体瘤, 胃癌, 食道癌 详情
YL-17231 YL-17231; YL17231; TEB-17231 临床一期 上海璎黎药业有限公司 实体瘤, 肿瘤 详情
QTX-3034 QTX3034; QTX-3034 临床一期 Quanta Therapeutics Inc 实体瘤, 肿瘤 详情
RNA tumor vaccine (First Affiliated Hospital Bengbu Medical College) 临床一期 蚌埠医学院第一附属医院 实体瘤 详情
RMC-9805 RM-036; RMC-9805 临床一期 Revolution Medicines Inc 实体瘤, 肿瘤, 结直肠癌, 胰腺导管癌, 非小细胞肺癌 详情
LUNA-18 LUNA-18 临床一期 中外制药株式会社 实体瘤 详情
BEBT-607 C200825009-FP; BEBT-607 临床一期 广州必贝特医药股份有限公司 实体瘤, 结直肠癌, 非小细胞肺癌 详情
BI-1701963 BI-1701963 临床一期 Forma Therapeutics Holdings Inc 实体瘤, 结直肠癌 详情
CWG-59r CWG-59r; CWG-59-r; CWG59r 临床阶段不明 Cellworks Group 肿瘤 详情
CWG-71b CWG-71b; CWG-71-b; CWG71b 临床阶段不明 Cellworks Group 肿瘤 详情
CWG-89 CWG-89 临床阶段不明 Cellworks Group 肿瘤 详情
CWG-71a (Cellworks Group) CWG-71a 临床阶段不明 Cellworks Group Inc 肿瘤 详情

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