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TGF-beta 2信息

英文名称:Transforming growth factor beta 2
中文名称:转化生长因子β2
靶点别称:TGF-beta-2,BSC-1 Cell Growth Inhibitor,Polyergin,Glioblastoma-Derived T-Cell Suppressor Factor,Cetermin,LDS4,TGFB2,Transforming Growth Factor, Beta 2,Transforming Growth Factor Beta-2 Proprotein,TGF-Beta2,Transforming Growth Factor Beta 2,G-TSF,Transforming Growth Factor beta2,LAP,Prepro-Transforming Growth Factor Beta-2
上市药物数量:0
临床药物数量:6
最高研发阶段:临床三期

TGF-beta 2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
TG2-H4215
Human
Human TGF-Beta 2 / TGFB2 Protein, Tag Free
ACRO质量管理体系
 
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TGF-beta 2 分子别名

TGFB2,MGC116892,TGFβ2,TGF-beta2

TGF-beta 2 分子背景

Transforming growth factor beta 2 ( TGFB2) is also known as TGF-β2, G-TSF, TGFB. is a polypeptide member of the transforming growth factor beta superfamily of cytokines. It is a secreted protein that performs many cellular functions, including the control of cell growth, cell proliferation, cell differentiation and apoptosis. The TGFB2 protein helps control the growth and division (proliferation) of cells, the process by which cells mature to carry out specific functions (differentiation), cell movement (motility), and the self-destruction of cells (apoptosis). The TGFB2 protein can inhibit the T cell growth by IL-2-dependent. and can inhibit immune surveillance during tumor development, the protein promoting tumor growth with an autocrine manner. TGF-β2 can affect the viability of killer cells and reduce the expression of IL-2, IL-6, IL-10, IFN-γ and other cytokines.TGFB2 plays an important role in controlling the immune system, and shows different activities on different types of cell, or cells at different developmental stages.

TGF-beta 2 前沿进展

TGF-beta 2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Trabedersen OT-101; AP-2/09; AP-2/09-DS; AP-12009; OT-201 临床三期 胶质母细胞瘤, 胰腺癌, 新型冠状病毒感染, 间皮组织肿瘤, 星形细胞瘤, 结直肠癌, 肺癌, 胰腺导管癌, 黑色素瘤, 非小细胞肺癌 详情
Bintrafusp alfa M-7824; GSK-4045154; MSB-0011359C 临床三期 默克雪兰诺 肺癌, 肉瘤, 胆管上皮癌, 乳腺癌, 微卫星不稳定, 外阴肿瘤, 鼻咽癌, 前列腺癌, 结直肠癌, 口咽肿瘤, 胸腺肿瘤, 胆囊癌, 腺肌上皮瘤, 淋巴瘤, 脑转移, 泌尿生殖道肿瘤, 胸腺瘤, 非小细胞肺癌, 宫颈癌, 黑色素瘤, 转移癌, 生殖细胞和胚胎肿瘤, 卡波济氏肉瘤, 三阴性乳腺癌, 实体瘤, 血液肿瘤, 头颈癌, 肠道肿瘤, 头颈部鳞状细胞癌, 直肠癌, 肛门肿瘤, 胃癌, 转移性上皮癌, 肾细胞癌, 成感觉神经细胞瘤, 胆管癌, 肿瘤, 结肠癌, 小细胞肺癌, 人乳头瘤病毒感染, 尿路上皮癌, 鼻肿瘤, 神经胶质瘤, 胰腺癌, 去势抵抗性前列腺肿瘤, 膀胱癌 详情
Nisevokitug NIS-793 临床三期 Xoma Corp 肾肿瘤, 肝癌, 胰腺癌, 骨髓增生异常综合征, 小细胞肺癌, 乳腺癌, 结直肠癌, 骨髓纤维化, 胰腺导管癌, 肺癌, 腺癌 详情
ENERGI-F701 ENERGI-F701 临床二期 Energenesis Biomedical Co Ltd 脱发 详情
TU-2218 TU-2218 临床二期 TiumBio Co Ltd 实体瘤 详情
LP-008 LP-008 临床一期 实体瘤 详情

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