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 > 【Latent GDF-2】

Latent GDF-2产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
GD2-H52H3
Human
Human Latent GDF-2 / BMP-9 Protein, His Tag (MALS verified)
ACRO质量管理体系
 
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Latent GDF-2 分子别名

Latent GDF-2,Latent GDF2,Latent BMP-9,Latent BMP9

Latent GDF-2 分子背景

Human Growth and differentiation factor 2 (GDF-2), also known as Bone morphogenetic protein 9 (BMP-9), is a member of the BMP subgroup of the TGF-beta superfamily proteins that signal through heterodimeric complexes composed of type I and type II BMP receptors. GDF-2 Potent circulating inhibitor of angiogenesis. Signals through the type I activin receptor ACVRL1 but not other Alks. Signaling through SMAD1 in endothelial cells requires TGF-beta coreceptor endoglin/ENG. ALK1 is a signalling receptor for bone morphogenetic protein-9 (BMP-9) in endothelial cells (ECs). BMP-9 bound with high affinity to ALK1 and endoglin, and weakly to the type-I receptor ALK2 and to the BMP type-II receptor (BMPR-II) and activin type-II receptor (ActR-II) in transfected COS cells. Binding of BMP-9 to ALK2 was greatly facilitated when BMPR-II or ActR-II were co-expressed.

Latent GDF-2 前沿进展

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