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SDF-1信息

英文名称:C-X-C motif chemokine ligand 12
中文名称:C-X-C基序趋化因子配体12
靶点别称:Pre-B Cell Growth-Stimulating Factor,SDF1B,C-X-C Motif Chemokine Ligand 12,SDF1,SDF-1,Chemokine (C-X-C Motif) Ligand 12,Stromal Cell-Derived Factor 1,CXCL12,HSDF-1,SCYB12,C-X-C Motif Chemokine 12,IRH,TLSF,Chemokine CXCL12,TLSF-A,TLSF-B,SDF-1b,SDF-1a,Intercrine Reduced In Hepatomas,TPAR1,PBSF,HIRH,SDF1A
上市药物数量:0
临床药物数量:8
最高研发阶段:临床二期

SDF-1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SD1-H5143
Human
Human SDF-1 / CXCL12 Protein, His Tag
ACRO质量管理体系
 
评论(1)
SD1-H5143|Human SDF-1 / CXCL12 Protein, His Tag
  1. 188XXXXXXX7
  2. 0人赞
  3. Human SDF-1在五一回来的时候买的,急用,隔了一天就到了,解了我的燃眉之急。质量也超赞的,和R&D一样用,性价比很高
  4. 2023-05-16
 

SDF-1 分子别名

SDF-1,CXCL12,hSDF-1,IRH,hIRH,PBSF,SDF1,SDF1A,SDF1B

SDF-1 分子背景

Acts as a positive regulator of monocyte migration and a negative regulator of monocyte adhesion via the LYN kinase. Stimulates migration of monocytes and T-lymphocytes through its receptors, CXCR4 and ACKR3, and decreases monocyte adherence to surfaces coated with ICAM-1, a ligand for beta-2 integrins. SDF1A/CXCR4 signaling axis inhibits beta-2 integrin LFA-1 mediated adhesion of monocytes to ICAM-1 through LYN kinase. Inhibits CXCR4-mediated infection by T-cell line-adapted HIV-1. Plays a protective role after myocardial infarction. Induces down-regulation and internalization of ACKR3 expressed in various cells. Has several critical functions during embryonic development; required for B-cell lymphopoiesis, myelopoiesis in bone marrow and heart ventricular septum formation. Stimulates the proliferation of bone marrow-derived B-cell progenitors in the presence of IL7 as well as growth of stromal cell-dependent pre-B-cells

SDF-1 前沿进展

SDF-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Olaptesed Pegol NOX-A12 临床二期 Noxxon Pharma 造血干细胞移植, 胶质母细胞瘤, 胰腺癌, 多发性骨髓瘤, 结直肠癌, 慢性淋巴细胞白血病 详情
PTX-9908 PTX-9908 临床二期 Pertinax Therapeutics 肝细胞癌 详情
Emilimogene sigulactibac ILP100h 临床二期 Ilya Pharma AB 糖尿病足溃疡, 创伤和损伤 详情
JVS-100 JVS-100; SRX-100; ACRX-100; GP-51801; GP51801 临床一期 Cleveland Clinic 心脏衰竭, 缺血, 手术创口, 外周动脉疾病 详情
CK-0804 CK-0804 临床一期 Cellenkos Inc 骨髓纤维化 详情
Dociparstat sodium ODSH; CX-01; PGX-100; PGX-ODSH-2013-AML-1 临床一期 Paringenix 新型冠状病毒感染, 胰腺癌, 骨髓增生异常综合征, 蛋白丢失性肠病, 慢性阻塞性肺疾病, 急性髓细胞样白血病, 急性肺损伤 详情
MyoCell SDF-1 MyoCell SDF-1 临床阶段不明 U.S. Stem Cell 心脏衰竭 详情

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