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ALK-1信息

英文名称:Activin receptor-like kinase 1
中文名称:激活素受体样激酶-1
靶点别称:EC:2.7.11.30,ACVRLK1,Activin A Receptor Type II-Like 1,Activin A Receptor, Type II-Like Kinase 1,EC 2.7.11,ALK-1,Serine/threonine-protein kinase receptor R3,TGF-B superfamily receptor type I,Activin receptor-like kinase 1,SKR3,ALK1,ACVRL1,Activin A Receptor Like Type 1,Activin A Receptor Type IL,TSR-I,EC 2.7.11.30,HHT2,ORW2,HHT
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

ALK-1产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
AL1-H5228
Human
Human ALK-1 / ACVRL1 Protein, His Tag
ACRO质量管理体系
 
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ALK-1 分子别名

ACVRL1,ACVRLK1,ALK-1,HHT,HHT2,ORW2,SKR3,TSR-I

ALK-1 分子背景

Serine/threonine-protein kinase receptor R3 is an enzyme that in humans is encoded by the ALK1 gene. ALK1 is a receptor in the TGF beta signaling pathway. ALK1 protein is a receptor in the TGF beta signaling pathway. It plays an important role in vascular development, remodeling, and pathologic angiogenesis, play a role in stabilizing angiogenic vessels and contribute to resistance to anti-VEGF therapies, ALK1 blockade may represent an effective therapeutic opportunity complementary to the current antiangiogenic modalities in the clinic. Recently, researcher found that, ALK1-Fc inhibited BMP9-mediated Id-1 expression in human umbilical vein endothelial cells and inhibited cord formation by these cells on a Matrigel substrate, in a chick chorioallantoic membrane assay, ALK1-Fc reduced vascular endothelial growth factor-, fibroblast growth factor-, and BMP10-mediated vessel formation, and ALK1-Fc treatment reduced tumor burden in mice receiving orthotopic grafts of MCF7 mammary adenocarcinoma cells.

ALK-1 前沿进展

ALK-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Dalantercept ACE-041 临床二期 Acceleron Pharma Inc 卵巢癌, 实体瘤, 肾细胞癌, 头颈部鳞状细胞癌, 多发性骨髓瘤, 腹膜癌, 鳞状细胞癌, 输卵管癌, 子宫内膜癌, 腺癌, 子宫内膜样癌, 肝细胞癌 详情
Ascrinvacumab PF-3446962; GT-90001; PF-3-446-962; GT-90001C; ALK-1; GT90001C; PF-03446962 临床二期 辉瑞 实体瘤, 肝癌, 肿瘤, 间皮组织肿瘤, 结直肠癌, 肝细胞癌, 年龄相关性黄斑变性 详情

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