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 > 【IL-10 R alpha】

IL-10 R alpha信息

英文名称:Interleukin 10 receptor
中文名称:白细胞介素10受体
靶点别称:Receptors, Interleukin-10
上市药物数量:0
临床药物数量:8
最高研发阶段:临床三期

IL-10 R alpha分子别名

Interleukin-10 receptor subunit alpha,IL-10 receptor subunit alpha,IL-10R subunit alpha,IL-10RA,CDw210a,Interleukin-10 receptor subunit 1,IL-10R subunit 1,IL-10R1,CD210,IL10RA,IL10R

IL-10 R alpha分子背景

Interleukin-10 receptor subunit alpha (IL-10 R alpha ) is a cell surface receptor for the cytokine IL-10 that participates in IL-10 mediated anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Upon binding to IL10, induces a conformational change in IL10RB, allowing IL10RB to bind IL10 as well.In turn, the heterotetrameric assembly complex, composed of two subunits of IL10RA and IL10RB, activates the kinases JAK1 and TYK2 that are constitutively associated with IL10RA and IL10RB respectively.These kinases then phosphorylate specific tyrosine residues in the intracellular domain in IL10RA leading to the recruitment and subsequent phosphorylation of STAT3.

IL-10 R alpha临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
PEG-ilodecakin AM-0010 临床三期 默沙东, Armo Biosciences 实体瘤, 卵巢癌, 韦格纳肉芽肿, 肾细胞癌, 胰腺癌, 肿瘤, 血管炎, 前列腺癌, 乳腺癌, 结直肠癌, 非小细胞肺癌, 黑色素瘤 详情
AG-019 AG-019 临床二期 Precigen Actobio Inc 一型糖尿病 详情
IBB-0979 IBB0979; IBB-0979 临床二期 盛禾(中国)生物制药有限公司 实体瘤, 肿瘤 详情
IAE-0972 IAE-0972 临床二期 盛禾(中国)生物制药有限公司 实体瘤, 肝细胞癌 详情
Vimekofusp AMT-101 (Applied Molecular Transport) 临床二期 Applied Molecular Transport 溃疡性结肠炎 详情
Recombinant anti-human EGFR antibody/IL-10 bispecific Fc fusion protein(Dingfu Biotarget) CmAb-(IL10)2; DF203; DF-203 临床一期 苏州丁孚靶点生物技术有限公司 实体瘤 详情
Diakine-DK2 10 (EGFR) DK210; DK-2-10 临床一期 Deka Biosciences Inc 肾肿瘤, 实体瘤, 头颈癌, 肾细胞癌, 肿瘤, 胰腺癌, 皮肤肿瘤, 结直肠癌, 女性生殖系统癌症, 非小细胞肺癌 详情
F8-IL10 F8-IL10; PF-06687234 临床一期 Philogen Spa 炎症性肠疾病, 类风湿关节炎, 溃疡性结肠炎 详情

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