IFN-γ

Cytokine storm syndromes is an activation cascade of pro-inflammatory cytokines, such as TNF-α、IL-1、IL-6、IL-12、IFN-α、IFN-β、IFN-γ、MCP-1 and IL-8,due to unregulated host immune response system to different stimuli such as infections, malignancy, rheumatoid disorders, drugs, and so on. Interferon-γ (IFN-γ), one of the four subclasses ofinterferons, and is a multipotent protein, acting on many cell types by inducing or inhibiting many cellular functions through direct effects on gene expression.