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Neuropilin-2信息

英文名称:Neuropilin 2
中文名称:神经纤毛蛋白质-2
靶点别称:Neuropilin-2,Vascular endothelial cell growth factor 165 receptor 2,NPN2,NP2,Neuropilin-2a(22),Neuropilin-2b(0),VEGF165R2,PRO2714,Neuropilin-2a(17),Receptor For VEGF165 And Semaphorins Class3
上市药物数量:0
临床药物数量:1
最高研发阶段:临床三期

Neuropilin-2产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
NR2-H52H3
Human
Human Neuropilin-2 / NRP2 Protein, His Tag (MALS verified)
ACRO质量管理体系
 
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Neuropilin-2分子别名

Neuropilin-2,NRP2,VEGF165R2,Neuropilin2,Vascular endothelial cell growth factor 165 receptor 2

Neuropilin-2分子背景

Neuropilin-1 (Npn-1, previously known as neuropilin) and Neuropilin-2 (previously known as Npn-1-related molecule) are type I transmembrane proteins that bind distinct members of the class III secreted semaphorin subfamily that are implicated in repulsive axon guidance. Neuropilin extracellular domains contain two CUB (complement-binding) domains, two domains with homology to coagulation factors V and VIII, and a MAM (meprin) domain. In the absence of ligands, neuropilins can form homo- and hetero-oligomers via their MAM domains. Expression in developing neurons of the central and peripheral nervous systems is somewhat overlapping but distinct. Npn-1 and Npn-2 are also receptors for VEGF165 on endothelial and tumor cells.

Neuropilin-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Efzofitimod ATYR-1923; KRP-R120 临床三期 Atyr Pharma 新型冠状病毒感染, 间质性肺疾病, 肺结节病 详情

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