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Siglec-7 | J chain 分子别名

CDw328,D-siglec,A79 membrane protein,p75,Adhesion inhibitory receptor molecule 1,AIRM-1

Siglec-7 | J chain 分子背景

Siglec-7 is a member of the human CD33‐related Siglec receptor. The extracellular region of Siglec‐7 is characterized by an N‐terminal V‐set Ig domain that can bind sialic acid and two C2‐set Ig domains. The cytoplasmic tail of Siglec‐7 has one immune‐receptor tyrosine‐based inhibitory motif (ITIM) and one ITIM‐like motif. Siglec-7 is considered as a sialic acid-dependent immunoreceptor with inhibitory potential and expressed predominantly on human NK cells, monocytes and a small subset of CD8+ T cells.

Siglec-7 | J chain 前沿进展

Access to Orthopaedic Devices in Low and Middle-Income Countries: Challenges and Opportunities
Dworkin, Woolley, Shahab et al
J Bone Joint Surg Am (2025)
Abstract: ➢ Musculoskeletal injuries constitute a substantial proportion of worldwide disease, with access limited to many due to the availability and cost of devices. A multifaceted approach is needed to improve system-level access to care.➢ Although a number of procurement policies are utilized, providers in low and middle-income countries often struggle with inconsistent supply chains, leading to delays in care or less desirable management strategies.➢ Partnerships between governments, academic institutions, and nongovernmental agencies are needed to improve access to devices by providing funds for patients and creating regulatory bodies to ensure product quality and availability.➢ There should be a focus on local and regional manufacturing as well as job creation within low and middle-income countries to achieve sustainable access to orthopaedic devices.➢ High-quality research initiatives are needed to provide evidence-based solutions. This includes a focus on outcomes-based studies to determine best management practices within the low and middle-income countries' context and operations research to optimize systems for device procurement.Copyright © 2025 by The Journal of Bone and Joint Surgery, Incorporated.
Abruptness of tone onsets, but not offsets, elicits the auditory-induced bouncing/streaming illusion
Meyerhoff, Ockl, Frings et al
J Exp Psychol Hum Percept Perform (2025)
Abstract: The way we perceive the movement of two intersecting discs can be influenced by auditory information. When a brief tone is played while these discs overlap, people tend to report that the discs bounce off each other instead of streaming past each other. This is known as the auditory-induced bouncing/streaming illusion. Both perceptual/attentional and decisional processes have been discussed as explanations for the bouncing/streaming illusion. In four experiments, we study how the abruptness of tone onsets and offsets affects the bouncing/streaming illusion. We found that tones with more abrupt onsets and offsets resulted in a higher proportion of bouncing impressions than those with smoother ones (Experiment 1). This effect was not due to differences in loudness between the tones (Experiment 2). Additionally, we found that the abruptness of the tone onset, rather than the offset, caused the increase in bouncing impressions (Experiment 3). This effect was observed regardless of the temporal alignment of the tones with the moment of visual overlap (onset-aligned vs. centered vs. offset-aligned; Experiment 4). In sum, our results revealed evidence in favor of a chain of perceptual as well as decisional processes contributing to the reported bouncing/streaming impressions, and we discuss how both might interact during the resolution of the ambiguous bouncing/streaming display. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
A rare case of multiple myeloma with double translocations: t(11;14) and t(14;16)
Meseha, Patel, Sekla et al
J Hematop (2025) 18 (1), 11
Abstract: Multiple myeloma is a clonal plasma cell malignancy often characterized by complex cytogenetic abnormalities that influence prognosis and treatment strategies. This report describes a 63-year-old male with kappa light chain multiple myeloma and a rare finding of double translocation involving t(11;14) and t(14;16), detected by FISH analysis. This case emphasizes the clinical implications of such genetic abnormalities and their impact on disease progression and therapeutic decisions.© 2025. The Author(s).
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