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 > 【Angiogenin】

Angiogenin信息

英文名称:Cleavage and polyadenylation specificity factor subunit 3
中文名称:切割和聚腺苷酸特异性因子3
靶点别称:YSH1,Cleavage And Polyadenylation Specificity Factor 73 KDa Subunit,Cleavage And Polyadenylation Specific Factor 3, 73kD Subunit,CPSF 73 KDa Subunit,NEDMHSN,NEDMHS,EC 3.1.27,Cleavage and polyadenylation specificity factor 73 kDa subunit (CPSF 73 kDa subunit),mRNA 3'-end-processing endonuclease CPSF-73,CPSF73,Cleavage And Polyadenylation Specific Factor 3,CPSF-73,Cleavage And Polyadenylation Specificity Factor Subunit 3,Cleavage And Polyadenylation Specific Factor 3, 73kDa,MRNA 3'-End-Processing
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

Angiogenin产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
ANN-H5149
Human
Human Angiogenin / RNASE5 Protein, His Tag
ACRO质量管理体系
 
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Angiogenin 分子别名

ALS9,ANG,Angiogenin,angiogenin, ribonuclease, RNase A family, 5,EC 3.1.27,EC:3.1.27.-

Angiogenin 分子背景

Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo

Angiogenin 前沿进展

Angiogenin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
DNDI-6148 DNDI-6148 临床一期 Drugs For Neglected Diseases Initiative 感染, 皮肤利什曼病, 内脏利什曼病 详情
AN-3661 AN-6426; AN-3661 临床一期 Anacor Pharmaceuticals Inc 疟原虫感染 详情

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