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DXD产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
DXD-M684
Mouse		 Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (MALS verified)
DXD-BVM807
Mouse		 Biotinylated Anti-DXD&Exatecan Antibody, Mouse IgG1, Avitag™ (MALS verified)
DXD-PLM684
Mouse		 HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1
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评论(10)
DXD-PLM684|HRP conjugated Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1
  1. 185XXXXXXX6
    2. 1人赞
  2. 公司在做ADC项目，需要评估动物实验PK与药效关系，用本抗体进行ELISA实验定量不同时间ADC的血浆浓度。抗体特异、灵敏、实验非常成功。
  3. 2024-08-08
DXD-M684|Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (MALS verified)
  1. 153XXXXXXX7
    2. 1人赞
  2. 该产品用于抗体偶联药物药代动力学样品ADC的检测，作为包被试剂，空白响应底，特异性高，EC50较低，定量下限可以达到0.312mg/ml
  3. 2023-12-07
DXD-M684|Monoclonal Anti-DXD&Exatecan Antibody, Mouse IgG1 (MALS verified)
  1. 153XXXXXXX8
    2. 0人赞
  2. 购买的这款产品主要用于ADC检测，应用于elisa研究，实验结果很好，对产品很满意，就是有点小贵，不过产品质量和服务倒是非常不错滴
  3. >
  4. 2024-08-02
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DXD分子别名

DXD

DXD分子背景

Dxd (Exatecan ADC derivative) is a potent DNA topoisomerase I inhibitor with an IC50 of 0.31 uM for targeting ADCs (DS-8201A). Dxd was cytotoxic to human tumor cell lines KPL-4, NCI-N87 and SK-BR, 3 and the IC50s of MDA-MB-468 was 1.43 NM-4.07 nM, while lgGADC (Dxd as payload) had no inhibitory effect on HER2 expression in the 4 cell lines. DS8201a (Dxd as payload) had a significant inhibitory effect on HER2-positive KPL-4 and NCI cell lines N87 and SK-BRwith IC50 values of 26.8, 25.4 and 6.7 ng/mL, respectively, but had no inhibitory effect on MDA MB-468 (IC50, > 10000 - mL). HRP-anti-DXD-antibody is a conjugation product of HRP and anti-DXD-antibody. It can be used in PK, PD analysis and ELISA.

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