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MMP-3信息

英文名称:Matrix metalloproteinase 3
中文名称:基质金属蛋白酶-3
靶点别称:CHDS6,STR1,STMY,Matrix Metalloproteinase 3,Matrix metalloproteinase-3,MMP-3,SL-1,STMY1,MMP3,Matrix Metalloproteinase 3 (Stromelysin 1, Progelatinase),Transin-1,Proteoglycanase,Stromelysin-1,Stromelysin 1,EC 3.4.24.17,EC:3.4.24.17,EC 3.4.24,Matrix Metallopeptidase 3
上市药物数量:0
临床药物数量:0
最高研发阶段:临床前

MMP-3产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
MM3-H52H3
Human
Human MMP-3 Protein, His Tag (active enzyme, MALS verified)
ACRO质量管理体系
 
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MMP-3分子别名

CHDS6

MMP-3分子背景

Matrix metalloproteinase 3 (MMP-3), also known as stromelysin 1 and progelatinase, is encoded by the MMP3 gene. The expression of MMP3 is mainly regulated at the transcriptional level, where gene promoters respond to a variety of stimuli including growth factors, cytokines, carcinogens and proto-oncogene products. MMP-3 degrade II, III, IV, IX and X collagen, proteoglycan, fibronectin, laminin, and elastin. In addition, MMP-3 can also activate other MMPs such as MMP-1, MMP-7 and MMP-9, so MMP-3 plays a key role in connective tissue remodeling. This enzyme is involved in wound repair, atherosclerotic progression, and tumor initiation. Studies of MMP-3 wild type and gene knockout in mice have shown that MMP-3 increases the permeability of the blood-brain barrier after traumatic injury. Nuclear MMP-3 works as a transcription factor and protease.

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