Recombinant Proteins iso9001 ISO13485
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 > 【Dkk-3】重组蛋白信息

Dkk-3信息

英文名称:Dickkopf-related protein 3
中文名称:Dickkopf相关蛋白3
靶点别称:UNQ258/PRO295,Dickkopf-3,Dickkopf-related protein 3,hDkk-3,REIC,DKK3,Dickkopf WNT Signaling Pathway Inhibitor 3,Regulated In Glioma,Dkk-3,Dickkopf (Xenopus Laevis) Homolog 3,Dickkopf 3 Homolog,Dickkopf Homolog 3,RIG-Like 5-6,RIG-Like 7-1,RIG,Dickkopf 3 Ho
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Dkk-3产品列表

产品库
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
DK3-M5226
Mouse
Mouse Dkk-3 Protein, His Tag
DK3-H5220
Human
Human Dkk-3 (R335G) Protein, His Tag
 
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Dkk-3 分子别名

DKK3,REIC,RIG

Dkk-3 分子背景

Members of the dickkopf-related protein family (DKK-1, -2, -3, and -4) are secreted proteins with two cysteine-rich domains separated by a linker region. And DKK3 has been proposed as tumour suppressor gene and a marker for tumour blood vessels. DKK3 is the only DKK family member abundantly expressed in normal lung, but silenced by promoter hypermethylation in a large fraction of lung cancer cell lines and lung tumors. Downregulation of DKK3 was correlated with tumor progression and expression of nuclear beta-catenin in lung tumors. Ectopic expression of DKK3 in lung cancer cells with DKK3 hypermethylation induced apoptosis and inhibited TCF-4 activity as well as nuclear accumulation of beta-catenin and expression of TCF-4 targets c-Myc and cyclin D1. DKK3 modulates FGF and Activin/Nodal signaling to regulate mesoderm induction during early Xenopus development, was reported.

Dkk-3 参考文献

Dkk-3临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Ad-SGE-DKK3 gene therapy Ad-SGE-DKK3; Ad-SGE-REIC 临床二期 杏林 间皮组织肿瘤 详情
REIC gene therapy (Momotaro-Gene) MTG-201; Ad5-SGE-REIC/Dkk-3 临床二期 Momotaro-Gene 间皮组织肿瘤, 前列腺癌 详情

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