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Frizzled-2信息

英文名称:Frizzled-2
中文名称:卷曲蛋白-2
靶点别称:Frizzled Class Receptor 2,Frizzled 2, Seven Transmembrane Spanning Receptor,Frizzled Family Receptor 2,FzE2,Fz-2
上市药物数量:0
临床药物数量:1
最高研发阶段:临床一期

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Frizzled-2 分子别名

FZD2,Frizzled-2,Fz-2,hFz2,FzE2

Frizzled-2 分子背景

Frizzled-2 (FZD2) is also known as FzE2, which belongs to the G-protein coupled receptor Fz/Smo family. Most of frizzled receptors are coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK-3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. FZD2 contains one FZ (frizzled) domain. FZD2 may be involved in transduction and intercellular transmission of polarity information during tissue morphogenesis and/or in differentiated tissues. The Lys-Thr-X-X-X-Trp motif of FZD2 interacts with the PDZ doman of Dvl (Disheveled) family members and is involved in the activation of the Wnt/beta-catenin signaling pathway.

Frizzled-2 前沿进展

Frizzled-2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Vantictumab OMP-18R5; anti-Fzd7 临床一期 Oncomed Pharmaceuticals Inc, 拜耳 实体瘤, 胰腺癌, 乳腺癌, 非小细胞肺癌 详情

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