登录 | 注册    关注公众号  
微信公众号
搜索
 > 【ITPRIPL1】

ITPRIPL1产品列表

产品库
物种
属性
货号 物种 产品描述 蛋白结构 纯度 活性
IT1-H5253
Human
Human ITPRIPL1 Protein, Fc Tag (MALS verified)
IT1-H52H3
Human
Human ITPRIPL1 Protein, His Tag
ACRO质量管理体系
 
评论(0)
 

ITPRIPL1分子别名

KIAA1754L

ITPRIPL1分子背景

Inositol 1,4,5-triphosphate receptor interacting protein like 1 (ITPRIPL1) is a single transmembrane protein,exhibits normal testis-enriched expression and widespread overexpression in various human cancers. ITPRIPL1 is commonly found in tumors with low PD-L1 expression. ITPRIPL1 acts as a natural ligand for CD3 ε, evading immune surveillance, leading to decreased T cell activity and promoting tumor growth. Research has shown that inducing stable CD3E-NCK1 binding prevents CD3E-ZAP70 interaction, subsequently inhibiting downstream ERK-NFkB signaling cascade and calcium influx activation.

消息提示

请输入您的联系方式,再点击提交!

确定