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Flt-3 Ligand信息

英文名称:Fms-related tyrosine kinase 3 ligand
中文名称:Flt3配体
靶点别称:Flt3L,SL cytokine,FLT3LG
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

Flt-3 Ligand产品列表

ACRO质量管理体系
 
评论(2)
FLL-H5218|Human Flt-3 Ligand Protein, premium grade
  1. 158XXXXXXX6
  2. 3人赞
  3. 包装很有质感;说明书上推荐的是用去离子水溶解,使用很便利;目前是用于分化实验,细胞培养过程中没有发现什么问题,后续可能会补充。
  4. 2021-10-13
FLL-H82E6|Biotinylated Human Flt-3 Ligand Protein, His,Avitag™ (MALS verified)
  1. 173XXXXXXX9
  2. 2人赞
  3. 一直购买Acro产品,在使用过程中非常稳定,检测速度快,结合能力强,大大提升实验进度,为开发过程节省了不少时间!
  4. 2023-03-30
 

Flt-3 Ligand分子别名

FLT3LG,FL,FLT3L,Flt3 ligand

Flt-3 Ligand分子背景

FMS-like tyrosine kinase 3 ligand (Flt-3 Ligand) is also known as FL, Flt3L and FLT3LG, is an α-helical cytokine that promotes the differentiation of multiple hematopoietic cell lineages. FLT3LG is expressed as a noncovalentlylinked dimer by T cells and bone marrow and thymic fibroblasts. Each 36 kDa chain carries approximately 12 kDa of N- and O- linked carbohydrates. FLT3LG is structurally homologous to stem cell factor (SCF) and colony stimulating facor 1 (CSF-1). FLT3LG acts as a growth factor that increases the number of immune cells by activating the hematopoietic progenitors. It also induces the mobilization of the hematopoietic progenitors and stem cells in vivo which may help the system to kill cancer cells. FLT3LG induces the expansion of monocytes and immature dendritic cells as well as early B cell lineage differentiation. FLT3LG cooperates with IL2, IL6, IL7, and IL15 to induce NK cell development and with IL3, IL7 and IL11 to induce terminal B cell maturation. Animal studies also show FLT3LG to reduce the severity of experimentally induced allergic inflammation. FLT3LG is crucial for steady-state pDC and cDC development. A lack of FLT3L results in low levels of DCs.

Flt-3 Ligand临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
VIB-1116 VIB-1116; AMG 329; HZN-1116 临床二期 Viela Bio Inc 自身免疫疾病, Sjtoegren综合征 详情

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