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S100A8信息

英文名称:S100 calcium binding protein A9
中文名称:钙结合蛋白S100A9
靶点别称:Protein S100-A9,CAGB,MRP-14,S100 calcium-binding protein A9,p14,S100A9,S100 Calcium Binding Protein A9,Migration Inhibitory Factor-Related Protein 14,Leukocyte L1 Complex Heavy Chain,Calprotectin L1H Subunit,MRP14,CFAG,S100 Calcium-Binding Protein A9 (Calgranulin B),Calgranulin-B,60B8AG,MAC387,CGLB,L1AG,LIAG,MIF,NIF,Calgranulin B
上市药物数量:0
临床药物数量:1
最高研发阶段:临床二期

S100A8产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
S18-H5112
Human
Human S100A8 Protein, Tag Free
ACRO质量管理体系
 
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S100A8 分子别名

S100A8,60B8AG,CAGA,CFAG,CGLA,CP-10,MRP8,NIF,P8

S100A8 分子背景

S100 calcium binding protein A8 (S100-A8) is also kown as Cystic fibrosis antigen, Migration inhibitory factor-related protein 8 60B8AG, CAGA, CFAG, CGLA, CP-10, L1Ag, MA387, MIF, MRP8, NIF and P8, is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. Most S100 proteins are disulfide-linked homodimer, and is normally present in cells derived from the neural crest, chondrocytes, macrophages, dendritic cells, etc. S100A8 plays a role in various functions of myeloid cells by forming a heterocomplex with S100A9. S100A8 and S100A9 are known to be overexpressed in certain species of carcinomas. S100A8 may function in the inhibition of casein kinase and as a cytokine. Altered expression of this protein is associated with the disease cystic fibrosis. S100A8 plays an important role in differentiation of thyroid carcinoma possibly by forming a complex with S100A9. S100A8 and S100A9 may also play a key role in inflammation-associated cancer.

S100A8 前沿进展

S100A8临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Tasquinimod ABR-215050; TASQ; ABR-5050 临床二期 Active Biotech Ab 卵巢癌, 肾细胞癌, 胃癌, 去势抵抗性前列腺肿瘤, 多发性骨髓瘤, 前列腺癌, 骨髓纤维化 详情

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