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Sonic Hedgehog信息

英文名称:Sonic Hedgehog Homolog
中文名称:SHH
靶点别称:HHG-1,Shh unprocessed N-terminal signaling and C-terminal autoprocessing domains,ShhNC,Shh N-terminal processed signaling domains,ShhNp,ShhN,Sonic hedgehog protein,Sonic hedgehog protein N-product,Sonic Hedgehog Signaling Molecule,Sonic Hedgehog (Drosophila) Homolog
上市药物数量:0
临床药物数量:5
最高研发阶段:临床二期

Sonic Hedgehog产品列表

产品库
物种
标签
属性
货号 物种 产品描述 蛋白结构 纯度 活性
SH7-H5229
Human
Human Sonic Hedgehog / Shh Protein, His Tag, premium grade
ACRO质量管理体系
 
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Sonic Hedgehog分子别名

SHH,HHG-1,Sonic hedgehog,HLP3,HPE3,SMMCI,TPT,TPTPS

Sonic Hedgehog分子背景

Sonic hedgehog protein (SHH) is also known as HHG-1, which belongs to the hedgehog family. SHH is expressed in fetal intestine, liver, lung, and kidney and not expressed in adult tissues. Sonic hedgehog protein can be cleavage into sonic hedgehog protein N-product and sonic hedgehog protein C-product by autolysis. SHH binds to the patched (PTC) receptor, which functions in association with smoothened (SMO), to activate the transcription of target genes. In the absence of SHH, PTC represses the constitutive signaling activity of SMO. Also regulates another target, the gli oncogene. Intercellular signal essential for a variety of patterning events during development. The C-terminal domain displays an autoproteolysis activity and a cholesterol transferase activity. The N-product is the active species in both local and long-range signaling, whereas the C-product has no signaling activity.

Sonic Hedgehog临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Sulforadex SFX-01 临床二期 Pharmagra Labs Inc, Evgen Pharma, Lalilab 自闭症, 癌前状态, 左心室功能不全, 蛛网膜下腔出血, 血栓形成, 慢性肾功能不全, 肺癌, 增生, 帕金森病, 哮喘, 原位癌, 乳腺癌, 前列腺癌, 药物相关的副作用和不良反应, 肾脏疾病, 心脏病, 神经发育障碍, 肿瘤, 间变, 头颈部鳞状细胞癌, 鼻唇沟皱纹, 自闭症谱系障碍, 精神分裂症, 头颈癌, 舒张期心力衰竭 详情
ACC-006 ACC-006 临床二期 江苏艾迪药业股份有限公司, 中国药科大学 实体瘤, 非小细胞肺癌 详情
NLM-001 NLM-001 临床二期 Nelum Corp 胰腺导管癌 详情
IMP5471-CA 临床一期 上海瑛派药业有限公司 血液疾病 详情

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