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Syndecan-1信息

英文名称:Syndecan-1
中文名称:多配体蛋白聚糖-1
靶点别称:Syndecan Proteoglycan 1,CD138 Antigen,SYND1,SDC,Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor,Syndecan,CD138,Syndecan-1,SDC1,Syndecan 1
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

Syndecan-1分子别名

SDC1,Syndecan-1,CD138,SYND1,SDC

Syndecan-1分子背景

Syndecan-1 (SYND1 or SDC1) is also known as CD antigen CD138, is a transmembrane (type I) heparan sulfate proteoglycan and is a member of the syndecan proteoglycan family. The syndecans mediate cell binding, cell signaling, and cytoskeletal organization and syndecan receptors are required for internalization of the HIV-1 tat protein. The syndecan-1 / SDC1 protein functions as an integral membrane protein and participates in cell proliferation, cell migration and cell-matrix interactions via its receptor for extracellular matrix proteins. It is a useful marker for plasma cells, but only if the cells tested are already known to be derived from blood.

Syndecan-1临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CART-138 (Chinese PLA General Hospital) 临床二期 中国人民解放军总医院 肝癌, 卵巢癌, 胰腺癌, 多发性骨髓瘤, 急性淋巴细胞白血病, 乳腺癌, 脑癌, 结直肠癌 详情
ATLCAR.CD138 (UNC Lineberger Comprehensive Cancer Center) 临床一期 Unc Lineberger Comprehensive Cancer Center 多发性骨髓瘤, 免疫紊乱 详情

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