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TGF-beta RII信息

英文名称:Transforming growth factor beta receptor 2
中文名称:转化生长因子β受体2
靶点别称:NONHSAG034676,TGF-beta receptor type II,Transforming Growth Factor Beta Receptor 2,Transforming Growth Factor, Beta Receptor II Alpha,Transforming Growth Factor Beta Receptor Type IIC,Transforming growth factor-beta receptor type II,TbetaR-II,TGF-beta type II receptor,TGFBR2,Transforming Growth Factor, Beta Receptor II (70/80kDa),Transforming Growth Factor Beta Receptor II,TGFR-2,Transforming Growth Factor, Beta Receptor II Epsilon,Transforming Growth Factor, Beta Receptor II Delta,Transforming
上市药物数量:0
临床药物数量:4
最高研发阶段:临床二期

TGF-beta RII产品列表

ACRO质量管理体系
 
评论(2)
TG2-H52H5|Human TGF-beta RII / TGFBR2 Protein, His Tag (MALS verified)
  1. 857XXXXXXX13
  2. 1人赞
  3. I ordered Acro’s human TGF-beta Receptor II for Octet kinetics binding assays for several assays. Delivery was extremely quick and customer service was very responsive to questions I had. I first used this TGF-beta RII in an Octet binding kinetics assay and received high quality results that were consistent with what I expected. I also used this product as a TGF-beta sink in cytotoxicity assays. I have been impressed by the quality of Acro’s products.
  4. 2022-08-17
TG2-H52H5|Human TGF-beta RII / TGFBR2 Protein, His Tag (MALS verified)
  1. 135XXXXXXX2
  2. 0人赞
  3. 用过很多次acro家的产品,这个蛋白用于细胞功能实验,活性好,实验内表现出非常好的活性和灵敏度。
  4. 2021-10-22
 

TGF-beta RII分子别名

TGFBR2,TGFR2,TbetaR-II,TGFβR2

TGF-beta RII分子背景

TGF-beta receptor type-2 (TGFBR2 or TGFR-2) is also known as TGF-beta type II receptor, Transforming growth factor-beta receptor type II, TbetaR-II, TGFβR2, which is a homodimer or heterohexamer, belongs to the protein kinase superfamily, TKL Ser/Thr protein kinase family and TGFB receptor subfamily. TGFR2 / TGFBR2 binds TGF-β1 / TGFB1 and TGF-β3 / TGFB3 with high affinity and TGF-β2 / TGFB2 with a much lower affinity. This type I I receptor forms a heterodimeric complex with type I receptor and is essential for signal transduction. Upon ligand binding, the TGFR2 autophosphorylates its cytoplasmic domain and subsequently phosphorylates the downstream molecules which then enter the nucleus and regulate the transcription of a subset of genes related to cell proliferation.

TGF-beta RII临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
HCW-9218 HCW-9218 临床二期 HCW Biologics Inc 实体瘤, 胰腺癌, 肺纤维化 详情
INCA33890 INCA33890; INCA-33890 临床一期 Incyte Corp 实体瘤, 肿瘤, 转移癌 详情
RG-6315 RG-6315 临床一期 基因泰克 系统性硬皮病 详情
TASO-001 TASO-001; ATB-301 临床一期 Autotelicbio Co Ltd 实体瘤 详情

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