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DNP 分子别名

DNP,Dinitrophenyl

DNP 分子背景

A hapten is a small molecule that can elicit an immune response only when conjugated with a large carrier such as a protein. Typical haptens include drugs, urushiol, quinone, steroids, etc. Peptides and non-protein antigens usually need conjugating to a carrier protein (such as BSA (bovine serum albumin) or KLH (keyhole limpet hemocyanin) to become good immunogens). Additionally, haptens should be administered with an adjuvant to ensure a high quality immune response. It is important that the hapten design (preserving greatly the chemical structure and spatial conformation of target compound), selection of the appropriate carrier protein and the conjugation method are key conditions for the desired specificity anti-hapten antibodies. We design anti-hapten antibodies based on the HaptenDB information.

DNP 前沿进展

Homogeneous dual-mode ECL-FL sensor for sensitive hydrogen sulfide detection: Mechanistic insights and applications in environmental and bioanalytical monitoring
Li, Wang, Yin et al
J Hazard Mater (2025) 491, 137939
Abstract: A dual-mode electrochemiluminescence (ECL) and fluorescence (FL) probe was developed based on functionalized metal-organic framework nanosheets (RuMOFNSs) and (3-((2,4-dinitrophenyl)thio)phenyl)methanol (DNB) for the highly sensitive detection of hydrogen sulfide (H₂S) in homogeneous systems. Compared to conventional heterogeneous detection strategies, the homogeneous nature of this probe eliminates signal loss associated with solid-phase immobilization, thereby enhancing the interaction efficiency between the probe and target molecules. The developed sensing platform exhibited exceptional sensitivity, achieving detection limits of 0.18 pM in ECL and 0.4 nM in FL, with recovery rates ranging from 96.1 % to 101.7 %. Moreover, the probe demonstrated high selectivity against potential interfering metal ions and proved effective for monitoring food spoilage and dynamic H₂S fluctuations in rat brain tissue. Compared to existing detection approaches, this dual-mode probe offers superior sensitivity, selectivity, and broader applicability, underscoring its potential for environmental and biomedical analyse.Copyright © 2025. Published by Elsevier B.V.
Development of a Biodegradable BODIPY-ε-Caprolactone System for Rapid Colorimetric Detection of Fluoride Ions in Environmental Samples
Kumar, Rajwar, Shunmugam
Chem Asian J (2025)
Abstract: Dental fluorosis, urolithiasis, and even cancer can result from excessive fluoride exposure. This is why monitoring fluoride levels is so important. A 2,4-dinitrophenyl hydrazine derivative of a BODIPY-based aldehyde system (BDNP) is a sensitive, ratiometric, and selective naked-eye sensor that we have developed for the quick detection of fluoride ions in biological and environment samples showed a significant color change from pink to grey and a significant redshift in absorbance maxima when interacting with fluoride ions. The notable color shift demonstrates the effectiveness of both BDNP and Poly-BDNP in detecting fluoride ions. Interestingly, here we also showed that the ring-opening polymerization (ROP) technique-synthesized biodegradable and biocompatible ε-Caprolactone homopolymer of BDNP (Poly-BDNP) is a great system that can detect fluoride ions colorimetrically with a higher limit of detection (LOD) value than the monomer and rapid detection ability. Using the UV-visible spectroscopy study and the 1H NMR spectroscopic titration technique, the interaction between BDNP and fluoride ions was examined. It was determined that the deprotonation of N-H protons triggers the intermolecular charge transfer (ICT) reaction, which results in the system's dramatic color change.© 2025 Wiley‐VCH GmbH.
GCMS, phytochemical analysis, biological potential of dichloromethane extract of Yucca elephantipes regel roots: in vitro and in silico studies
Khan, Jabeen, Siddique et al
Nat Prod Res (2025)
Abstract: tThe present research verified the presence of important phytochemicals in the dichloromethane extract of Y. elephantipes Regel roots through qualitative screening, GC-MS analysis, and evaluation of antioxidant and anti-inflammatory potential. Phytochemical analysis confirmed flavonoids, phenols, saponins, and tannins. GC-MS detected 41 components, including benzaldehyde 2,4-dinitrophenyl hydrazone (100%), heptanoic acid docosyl ester (83.01%), phthalic acid benzyl isobutyl ester (77.41%), stigmasterol (23.37%), and cholesterol (22.04%). Antioxidant activity was determined by hydrogen peroxide and ferrous reducing assays. The extract showed antioxidant activity increased in concentration-dependent manner with 67.94 ± 1.04% inhibition in the hydrogen peroxide assay and 71.51 ± 0.69% in the ferrous reducing assay, compared to ascorbic acid 85.14 ± 0.82% and 86.75 ± 1.05%, respectively. The extract exhibited significant anti-inflammatory activity (55.04 ± 2.3%, IC50 = 29.2 ± 2.4 µg/ml) via the ROS method, compared to ibuprofen (73.20 ± 1.7%, IC50 = 11.2 ± 1.9 µg/ml). Molecular docking explored ligand-target interactions, while SwissADME predicted ADME properties. These findings highlight Y. elephantipes as a source of phytochemicals with potential antioxidant and anti-inflammatory applications for oxidative stress and inflammatory conditions..
Showing 1-3 of 4246 papers.
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