Recombinant Proteins iso9001 ISO13485
搜索
 > 【DDR2】重组蛋白信息

DDR2信息

英文名称:Discoidin domain-containing receptor 2
中文名称:盘状结构域受体-2
靶点别称:CD167b,NTRKR3,CD167 Antigen-Like Family Member B,Discoidin Domain Receptor 2,Hydroxyaryl-Protein Kinase,CD167b Antigen,Discoidin Domain-Containing Receptor 2,Tyrosine-Protein Kinase TYRO10,Discoidin Domain-Containing Receptor Tyrosine Kinase 2,TKT,Discoid
上市药物数量:1
临床药物数量:1
最高研发阶段:批准上市

DDR2产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
 
评论(0)
 

DDR2 分子别名

DDR2,CD167b,NTRKR3,TKT,TYRO10

DDR2 分子背景

Discoidin domain-containing receptor 2 (DDR2) is also known as CD167 antigen-like family member B (CD167b), Discoidin domain-containing receptor tyrosine kinase 2, Neurotrophic tyrosine kinase, receptor-related 3(NTRKR3), Tyrosine-protein kinase TYRO10, Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. DDR2 is required for normal bone development. DDR2 regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. DDR2 regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. DDR2 promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

DDR2 参考文献

DDR2上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Regorafenib Monohydrate 瑞戈非尼 BAY-73-4506; DAST 批准上市 拜耳 Stivarga, Resihance Mainland China 胃肠道间质瘤 Bayer Pharma Ag 2012-09-27 实体瘤, 直肠癌, 肾细胞癌, 结肠癌, 结直肠癌, 胃肠道间质瘤, 肝细胞癌, 胃肠道癌症 详情

DDR2临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
CG-806 CG-806; CG-026806 临床二期 Crystalgenomics Inc, Aptose 血液肿瘤, 非霍奇金淋巴瘤, 急性髓细胞样白血病, 慢性淋巴细胞白血病 详情

消息提示

请输入您的联系方式,再点击提交!

确定