登录 | 注册    关注公众号  
微信公众号
搜索
 > 【Integrin alpha V beta 5】

Integrin alpha V beta 5信息

英文名称:Integrin alpha-V/beta-5
中文名称:整合素α-2/β-5复合体
靶点别称:Receptors, Vitronectin
上市药物数量:0
临床药物数量:2
最高研发阶段:临床一期

Integrin alpha V beta 5产品列表

ACRO质量管理体系
 
评论(1)
IT5-H52W5|Human Integrin alpha V beta 5 (ITGAV&ITGB5) Heterodimer Protein, His Tag&Tag Free
  1. 153XXXXXXX5
  2. 1人赞
  3. 我们购买这个ITGAV&ITGB5蛋白,主要用来做蛋白结合和早期蛋白筛选相关的实验。包被该蛋白的ELISA实验,效果显示良好,出来了较好的S曲线,满足了相关筛选实验需求。
  4. 2024-08-05
 

Integrin alpha V beta 5分子别名

Integrin alpha V beta 5,ITGAV&ITGB5

Integrin alpha V beta 5分子背景

Integrin alpha V beta 5 (ITGAV & ITGB5) is expressed on a wide variety of cell types including keratinocytes, fibroblasts, adhesive monocytes, embryonic stem cells, and select endothelium and epithelium. ITGAV & ITGB5 binds ligands containing an RGD motif, notably vitronectin. Growth factors that increase PKC activity, such as VEGF or TGF alpha, promote ITGAV & ITGB5-mediated angiogenesis while alpha V beta 3, which may be expressed in the same cell, responds to FGF-basic and TNF alpha. An inhibitor of both down regulates tumor angiogenesis. During lung inflammation, up regulation of ITGAV & ITGB5 on myofibroblasts or infiltrating lymphocytes may contribute to fibrosis by freeing TGF beta from latency.

Integrin alpha V beta 5临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Risuteganib ALG-1001; AM011; AM-011(Allegro Ophthalmics) 临床一期 Allegro Ophthalmics Llc 糖尿病黄斑水肿, 地图状萎缩, 年龄相关性黄斑变性, 糖尿病视网膜病变 详情
177Lu-FF-58 177Lu-FF58; 177-Lu-FF-58; 177Lu-FF-58; [177Lu]Lu-FF58 临床一期 Advanced Accelerator Applications Sa 食道癌, 胃癌, 胶质母细胞瘤, 胰腺导管癌 详情

消息提示

请输入您的联系方式,再点击提交!

确定