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CD96信息

英文名称:T-cell surface protein tactile
中文名称
靶点别称:Cell surface antigen CD96,TACTILE,T Cell Activation, Increased Late Expression,CD96 Antigen,CD96 Molecule,T cell-activated increased late expression protein
上市药物数量:0
临床药物数量:2
最高研发阶段:临床二期

CD96分子别名

TACTILE

CD96分子背景

The progression of pancreatic cancer (PC) is significantly associated with tumor immune escape, which may be associated with nature killer (NK) cell dysfunction. CD226, CD96, and TIGIT, which share the ligand CD155, play important roles in the regulation of NK cell function. The present study was conducted to investigate the roles of these molecules in NK cells from PC patients.
TIGIT and CD96 together with the co-stimulatory receptor CD226 form a pathway that is analogous to the CD28/CTLA-4 pathway, in which shared ligands and differential receptor:ligand affinities fine-tune the immune response. Although the roles of TIGIT and CD96 as immune checkpoint receptors in T cell and natural killer cell biology are just beginning to be uncovered, accumulating data support the targeting of these receptors for improving anti-tumor immune responses. A clear understanding of the immune cell populations regulated by TIGIT and CD96 is key to the design of immunotherapies that target these receptors in combination with other existing immune checkpoint blockade therapies.
The dysfunction of CD96 may trigger C syndrome: A syndrome characterized by trigonocephaly, severe mental retardation, hypotonia, variable cardiac defects, redundant skin, and dysmorphic facial features, including upslanted palpebral fissures, epicanthal folds, depressed nasal bridge, and low-set, posteriorly rotated ears.

CD96临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
AGEN-1777 AGEN-1777; BMS-986442 临床二期 安帝君斯公司 实体瘤, 肿瘤, 非小细胞肺癌 详情
Nelistotug GSK-6097608; GSK-608; GSK’608 CD96; GSK’608 临床二期 葛兰素史克 头颈癌, 肿瘤 详情

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