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 > 【FcRn (FCGRT & B2M)】

FcRn (FCGRT & B2M)信息

英文名称：IgG receptor FcRn large subunit p51
中文名称：IgG受体FcRn大亚基p51
靶点别称：Alpha-Chain，FcRn，Major Histocompatibility Complex Class I-Like Fc Receptor，Immunoglobulin Receptor， Intestinal， Heavy Chain，Neonatal Fc-Receptor For Ig，FcRn Alpha Chain，FCGRT，IgG Fc fragment receptor transporter alpha chain，Neonatal Fc receptor，Fc Fragment Of IgG Receptor And Transporter，Transmembrane Alpha Chain Of The Neonatal Receptor，Fc Fragment Of IgG， Receptor， Transporter， Alpha，IgG receptor FcRn large subunit p51，Heavy Chain Of The Major Histocompatibility Complex Class I-Like Fc Recepto
上市药物数量：3
临床药物数量：3
最高研发阶段：批准上市

FcRn (FCGRT & B2M)产品列表

筛选结果
产品库
物种
标签
属性
标记
货号 物种 产品描述 蛋白结构 纯度 活性
FCM-H5283
Human		 Human FcRn / FCGRT&B2M Heterodimer Protein, Strep Tag&Tag Free (MALS & SPR verified)
CHEK-ATP079
Human		 HEK293/Human FcRn (FCGRT & B2M) Stable Cell Line
FCM-C82W9
Canine		 Biotinylated Canine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS & SPR verified)
CHEK-ATP132
Human		 HEK293/FcRn (FCGRT & B2M), GFP Tag Stable Cell Line
FCM-C5284
Cynomolgus / Rhesus macaque		 Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & MALS verified)
FCM-C52W8
Canine		 Canine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)
FCM-C52W9
Cynomolgus / Rhesus macaque		 Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified)
FCM-C82W3
Cynomolgus / Rhesus macaque		 Biotinylated Cynomolgus / Rhesus macaque FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCM-C82W5
Cynomolgus / Rhesus macaque		 Biotinylated Cynomolgus / Rhesus macaque FcRn Heterodimer Protein, His,Avitag™&Strep II Tag (HPLC&SPR&BLI verified)
FCM-H5286
Human		 Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & HPLC-verified)
FCM-H8286
Human		 Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag, ultra sensitivity (primary amine labeling) (HPLC & SPR verified)
FCM-H82W4
Human		 Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (SPR & BLI & HPLC verified)
FCM-H82W7
Human		 Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCM-M52W2
Mouse		 Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Twin-Strep Tag (MALS & BLI verified)
FCM-M52W8
Mouse		 Mouse FcRn / FCGRT&B2M Heterodimer Protein, His Tag (MALS & BLI verified)
FCM-M82W5
Mouse		 Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & BLI verified)
FCM-M82W6
Mouse		 Biotinylated Mouse FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Twin-Strep Tag (MALS & BLI-verified)
FCM-P5280
Porcine		 Porcine FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified)
FCM-R5287
Rat		 Rat FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (MALS & SPR verified)
FCM-R52W5
Rabbit		 Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Tag Free (MALS & SPR verified)
FCM-R82W6
Rabbit		 Biotinylated Rabbit FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™&Tag Free (MALS&SPR verified)
FCM-R82W7
Rat		 Biotinylated Rat FcRn / FCGRT&B2M Heterodimer Protein, Avitag™,His Tag&Strep II Tag (MALS & SPR verified)
FCN-B82W3
Bovine		 Biotinylated Bovine FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCN-F82W3
Feline		 Biotinylated Feline FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
FCN-H52W7
Human		 Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & BLI & MALS verified)
FRT-01
Human		 Human FcRn binding Kit (TR-FRET)
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评论(84)
FCM-H5286|Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag&Strep II Tag (SPR & BLI & HPLC-verified)
  1. 134XXXXXXX9
    2. 33人赞
  2. 买的这款FcRn产品主要是用Biacroe进行抗体产品的SPR方法开发，用了很多款产品进行过SPR的方法开发，ACRO的这款效果不错，结合力也比较强。今年ACRO的产品种类丰富了很多，2022加油！
  3. >
  4. 2022-01-05
FCM-H82W7|Biotinylated Human FcRn / FCGRT&B2M Heterodimer Protein, His,Avitag™ (MALS & SPR verified)
  1. 185XXXXXXX2
    2. 14人赞
  2. 一直都在ACRO买蛋白，活性数据和纯度比较有保证，长期合作伙伴了。用这个开发blocking,实验很成功，之前用过另一家，非特异性比较高，导致window过低。SA定点标记的，比自己kit标记的稳定很多。
  3. >
  4. 2021-01-14
FCN-H52W7|Human FcRn / FCGRT&B2M Heterodimer Protein, His Tag (SPR & BLI & MALS verified)
  1. 137XXXXXXX3
    2. 13人赞
  2. 我们用这个蛋白来检测抗体与FcRn的结合能力，仪器用的Octet Red，sensor是HIS1K，结合的很好。
  3. 2019-10-14
查看更多评论
 

FcRn (FCGRT & B2M)分子别名

FcRn,FCGRT & B2M

FcRn (FCGRT & B2M)分子背景

FCGRT & B2M heterodimer protein (FcRn complex) consist of two subunits: p51 (equivalent to FCGRT), and p14 (equivalent to beta-2-microglobulin), and forms an MHC class I-like heterodimer. Fc fragment of IgG, receptor, transporter, alpha (FCGRT) binds to the Fc region of monomeric immunoglobulins gamma and mediates the uptake of IgG from milk. FCGRT possible role in transfer of immunoglobulin G from mother to fetus. Beta-2-microglobulin (B2M) is a component of the class I major histocompatibility complex (MHC) and involved in the presentation of peptide antigens to the immune system.

FcRn (FCGRT & B2M)上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Efgartigimod alfa 艾加莫德α ARGX-113; EFG PH20; EFG PH20 SC; PH20 SC 批准上市 Argenx Se VYVGART HYTRULO, Vyvgart, 卫伟迦, VYVGART United States 重症肌无力 Argenx BV 2021-12-17 体位性心动过速综合征, 心动过速, 天疱疮, 肾病综合征, 肌病, 格林-巴利综合征, 血小板减少, 大疱性类天疱疮, 膜性肾小球肾炎, 甲状腺相关性眼病, 狼疮肾炎, 慢性炎症性脱髓鞘性多发性神经病, Sjtoegren综合征, 自身免疫疾病, 多发性神经病, 肾病, 皮肌炎, 肌炎, 多发性肌炎, 重症肌无力, 特发性血小板减少性紫癜 详情
Rozanolixizumab 罗泽利昔珠单抗 UCB-7665 批准上市 比利时联合化工集团 RYSTIGGO United States 重症肌无力 Ucb Inc 2023-06-27 慢性炎症性脱髓鞘性多发性神经病, 特发性血小板减少性紫癜, 重症肌无力, 血小板减少, 胶质瘤, 纤维肌痛, 脑炎 详情
Efgartigimod alfa/Hyaluronidase 艾加莫德α/透明质酸酶 批准上市 Argenx BV VYVDURA, VYVGART HYTRULO United States 重症肌无力 Argenx BV 2023-06-20 重症肌无力 详情

FcRn (FCGRT & B2M)临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Nipocalimab M-281; JNJ-80202135 临床三期 Momenta 慢性炎症性脱髓鞘性多发性神经病, 重症肌无力, 溶血, 肌炎, 类风湿关节炎, Sjtoegren综合征, 狼疮肾炎, 自身免疫性溶血性贫血, 系统性红斑狼疮, 大疱性类天疱疮 详情
IMVT-1402 HL-161 ANS; IMVT-1402 临床一期 Immunovant Sciences Gmbh, HanAll Biopharma Co Ltd 自身免疫疾病 详情

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