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 > 【EphB4】

EphB4信息

英文名称：Ephrin type-B receptor 4
中文名称：B型肝配蛋白受体-4
靶点别称：Ephrin type-B receptor 4，MYK1，EPHB4，HTK，EPH Receptor B4，Tyrosine-Protein Kinase TYRO11，TYRO11，Tyrosine-Protein Kinase Receptor HTK，Soluble EPHB4 Variant 2，Soluble EPHB4 Variant 3，Ephrin Receptor EphB4，EC 2.7.10.1，HFASD，LMPHM7，CMAVM2，EC 2.7.10，EC:2.7.10.1，Soluble EPHB4 Variant 1，Receptor， EphB4，Hepatoma transmembrane kinase
上市药物数量：0
临床药物数量：1
最高研发阶段：临床三期

EphB4产品列表

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货号 物种 产品描述 蛋白结构 纯度 活性
EP4-H5229
Human		 Human EphB4 Protein, His Tag
EP4-H8229
Human		 Biotinylated Human EphB4 Protein, His Tag, ultra sensitivity (primary amine labeling)
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EphB4分子别名

EphB4,HTK,MYK1,TYRO11

EphB4分子背景

Ephrin type-B receptor 4(EPHB4) is also known as HTK, MYK1 and TYRO11,is a member of Eph family. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by EPHB4 binds to Ephrin-B2 and plays an essential role in vascular development. EPHB4 and its ligand ephrin-B2 are specifically expressed on venous and arterial endothelial cells, respectively, and play an essential role in vascular development via bidirectional signals. The forward EPHB4 signaling inhibits cell adhesion, chemotaxis, angiogenesis and tumor growth. Incontrast, the reverse Ephrin-B2 signaling exerts the opposite effect. It has been reported that aberrant expression of EPHB4 is associated with prostate cancer and highly malignant breast cancers, accordingly, EPHB4 has potential application as a therapeutic candidate.

EphB4临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
sEphB4-HSA Vas-01; sEphB4-HSA 临床三期 Vasgene 前列腺癌, 骨髓增生异常-骨髓增生性疾病, 卡波济氏肉瘤, 非小细胞肺癌, 急性髓细胞样白血病, 胆囊癌, 胆道癌, 肉瘤, 前体T-淋巴母细胞性淋巴瘤白血病, 急性淋巴细胞白血病, 慢性髓细胞白血病, 去势抵抗性前列腺肿瘤, 膀胱癌, 尿路上皮癌, 胰腺癌, 头颈部鳞状细胞癌, 肾细胞癌, 骨转移, 实体瘤 详情
Tesevatinib XL-647; KD-020; KD-019; EXEL-7647 临床二期 Exelixis Inc 肿瘤, 胶质母细胞瘤, 乳腺癌, 脑癌, 常染色体显性多囊肾病, 脑转移, 转移癌, 常染色体隐性遗传性多囊肾, 非小细胞肺癌 详情

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