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Mesothelin信息

英文名称:Mesothelin
中文名称:间皮素
靶点别称:Pre-pro-megakaryocyte-potentiating factor,Mesothelin,MSLN,CAK1 Antigen,MPF,Soluble MPF Mesothelin Related Protein,Megakaryocyte Potentiating Factor,SMRP,CAK1
上市药物数量:0
临床药物数量:36
最高研发阶段:临床二期

Mesothelin产品列表

货号 物种 产品描述 蛋白结构 纯度 活性
MSN-H82E9
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
MSN-HP2H5
Human
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-H82E7
Human
Biotinylated Human Mesothelin / MSLN (296-600) Protein, His,Avitag™ (MALS verified)
CEA-B030
Human
ClinMax™ Human Soluble Mesothelin ELISA Kit, PRO
CHEK-ATP119
Human
HEK293/Human Mesothelin Stable Cell Line
MBS-C003
Human
ActiveMax® Human MSLN μBeads, premium grade (for cells)
MBS-K024
Human
Human Mesothelin-coupled Magnetic Beads
MSN-C52H6
Cynomolgus
Cynomolgus Mesothelin / MSLN (296-580) Protein, His Tag (MALS verified)
MSN-H5222
Human
Human Mesothelin / MSLN (37-286) Protein, His Tag
MSN-H522a
Human
Human Mesothelin / MSLN (296-580) Protein, His Tag, premium grade
MSN-H5253
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag, premium grade
MSN-H5267
Human
Human Mesothelin / MSLN (391-598) Protein, Fc Tag (MALS verified)
MSN-H526x
Human
Human Mesothelin / MSLN (296-580) Protein, Fc Tag (MALS verified)
MSN-H8223
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, His Tag, ultra sensitivity (primary amine labeling)
MSN-H826x
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc Tag, ultra sensitivity (primary amine labeling) (MALS verified)
MSN-H82F6
Human
Biotinylated Human Mesothelin / MSLN (296-580) Protein, Fc,Avitag™, premium grade
MSN-HA2H5
Human
Alexa Fluor™ 647-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H6
Human
APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H7
Human
APC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
MSN-HA2H8
Human
Alexa Fluor™ 555-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HA2H9
Human
Alexa Fluor™ 488-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HF223
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HF253
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF25x
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, Fc Tag
MSN-HF2H3
Human
FITC-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HG2P4
Human
GFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-HP2H8
Human
PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His TagStar Staining
MSN-HR2P4
Human
RFP Fusion Human Mesothelin / MSLN (296-580) Protein, His Tag
MSN-M5254
Mouse
Mouse Mesothelin / MSLN Protein, Fc Tag
MSN-M52H3
Mouse
Mouse Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
MSN-M82E7
Mouse
Biotinylated Mouse Mesothelin / MSLN Protein, His,Avitag™
MSN-R52H4
Rat
Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
SCCHO-ATP120
Human
CHO/Human Mesothelin Stable Cell Line Development Service
ACRO质量管理体系
 
评论(27)
MSN-H82E9|Biotinylated Human Mesothelin / MSLN (296-580) Protein, His,Avitag™, premium grade
  1. 187XXXXXXX9
  2. 6人赞
  3. 使用该抗体对细胞产品进行流式检测,分析细胞阳性率。结果显示,该抗体特异性强,阳性群分群明显,下图显示在使用量为0.5微升时,细胞流式结果。
  4. >
  5. 2022-01-29
MSN-HP2H5|PE-Labeled Human Mesothelin / MSLN (296-580) Protein, His Tag (Site-specific conjugation)
  1. 138XXXXXXX6
  2. 3人赞
  3. 我们已使用Acro品牌的MSLN生物素化间标抗原及PE直标抗原用于流式实验检测,并考察了生物素化间标的稳定性,结果显示-80度条件保存4个月稳定性仍很好。
  4. >
  5. 2021-09-16
MSN-R52H4|Rat Mesothelin / MSLN (298-600) Protein, His Tag (MALS verified)
  1. 156XXXXXXX8
  2. 2人赞
  3. 我们采购大鼠的MSLN蛋白,主要是用于杂交瘤平台筛选MSLN的药用抗体分子,主要是用在前期的筛选阶段,检测我们通过杂交瘤筛选获得的抗体的种属交叉情况,通过ELISA检测是否在结合人的MSLN的同时,也可以结合大鼠的MSLN,从而支持后期在大鼠上开展毒理实验。
  4. 2022-04-06
 

Mesothelin分子别名

MSLN,Mesothelin,MPF

Mesothelin分子背景

Mesothelin (MSLN) is also known as CAK1 antigen, Pre-pro-megakaryocyte-potentiating factor, which belongs to the mesothelin family. Mesothelin / MSLN can be proteolytically cleaved into the following two chains by a furin-like convertase: Megakaryocyte-potentiating factor (MPF) and the cleaved form of mesothelin. Both MPF and the cleaved form of mesothelin are N-glycosylated. Mesothelin / MSLN can interacts with MUC16. The membrane-anchored forms of MSLN may play a role in cellular adhesion. MPF potentiates megakaryocyte colony formation in vitro.

Mesothelin临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
RC-88 RC-88 临床二期 荣昌生物制药(烟台)股份有限公司 实体瘤, 肿瘤, 卵巢上皮癌, 腹膜癌, 输卵管癌 详情
iCasp9M28z iCasp9M28z 临床二期 Memorial Sloan Kettering Cancer Center 小细胞肺癌, 肋膜疾病, 间皮组织肿瘤, 乳腺癌, 肺癌, 转移癌 详情
Anetumab ravtansine BAY-94-9343; BAY-94-9343-SPDB-DM4; Anti-mesothelin antibody-drug conjugate BAY 94-9343 临床二期 拜耳, Morphosys Ag 卵巢癌, 实体瘤, 浆液性囊腺癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 腹膜癌, 输卵管癌, 肺癌, 子宫内膜样癌 详情
Gavocabtagene autoleucel TC-210 临床二期 Tcr2 Therapeutics Inc 卵巢癌, 间皮组织肿瘤, 胆管上皮癌, 非小细胞肺癌 详情
LMB-100 LMB-100; RG-7787; RO-6927005 临床二期 罗氏 间皮肿瘤, 转移性上皮癌, 小细胞肺癌, 肺腺癌, 肿瘤, 胰腺癌, 间皮组织肿瘤, 胆管上皮癌, 肺癌, 恶性胸腔积液, 非小细胞肺癌 详情
anti-MESO CAR-T cells (Zhejiang University) UCLM802; UCLM-802 临床二期 浙江大学, 上海恒润达生生物科技股份有限公司 卵巢癌, 实体瘤 详情
Anti-CTLA-4 and PD-1 CAR-T cell therapy (Shanghai Cell Therapy Research Institute) 临床二期 上海细胞治疗研究院 肿瘤 详情
HPN-536 HPN-536 临床二期 Harpoon Therapeutics 肿瘤 详情
Autologous PD-1 antibody expressing mesothelin-targeted CAR-Tcells therapy (Shanghai Cell Therapy Research Institute) 临床二期 上海细胞治疗研究院 实体瘤 详情
CD40 ligand expressing MSLN-CAR T cells 临床二期 中国人民解放军总医院 实体瘤 详情
A2B-694 A2B-694; A2B694 临床二期 A2 Biotherapeutics Inc 实体瘤, 卵巢癌, 直肠癌, 肾细胞癌, 小细胞肺癌, 结肠癌, 胰腺癌, 肿瘤, 间皮组织肿瘤, 结直肠癌, 肺癌, 非小细胞肺癌 详情
RNA-Meso-CIR-T RNA-Meso-CIR-T 临床一期 诺华制药, 宾夕法尼亚大学 间皮组织肿瘤 详情
CART-meso CART-meso 临床一期 诺华制药, 宾夕法尼亚大学 卵巢癌, 转移性上皮癌, 肺腺癌, 卵巢上皮癌, 胰腺癌, 间皮组织肿瘤, 乳腺癌, 输卵管癌 详情
ABBV-428 ABBV-428; ABBV428 临床一期 艾伯维 实体瘤 详情
Anti-mesothelin thorium-227 labeled antibody chelator conjugate BAY-2287411 临床一期 拜耳 卵巢癌, 间皮组织肿瘤, 胰腺导管癌 详情
AB-1015 AB-1015 临床一期 Arsenal Biosciences Inc 卵巢癌, 卵巢上皮癌 详情
SynKIR-110 SynKIR™-110; SynKIR-meso 临床一期 Verismo Therapeutics Inc 卵巢癌, 间皮组织肿瘤, 胆管上皮癌 详情
KT-032 KT-032 临床一期 南京卡提医学科技有限公司 卵巢癌, 实体瘤, 胰腺癌, 间皮组织肿瘤 详情
JNJ-79032421 JNJ-79032421; JNJ-2421 临床一期 Janssen Research & Development Llc 实体瘤 详情
YL-215 YL215; YL-215 临床一期 苏州宜联生物医药有限公司 实体瘤 详情
GPC3/Mesothelin-CAR-γδT Cells therapy(Second Affiliated Hospital Of Guangzhou Medical University) 临床一期 广州医科大学附属第二医院 实体瘤, 肝癌, 小细胞肺癌, 胰腺癌, 间皮组织肿瘤, 肺癌 详情
AMG 305 AMG-305; AMG 305 临床一期 安进 实体瘤 详情
UCMYM-802 UCMYM802; UCMYM-802 临床一期 上海优替济生生物医药有限公司 实体瘤, 卵巢癌, 直肠癌, 胰腺癌, 间皮组织肿瘤, 乳腺癌, 结直肠癌, 胆道癌 详情
HBM-9033 HBM-9033; HBM9033 临床一期 诺纳生物 实体瘤 详情
Anti-mesothelin CAR T cell therapy (UTC Therapeutics Inc) 临床一期 UTC Therapeutics Inc 实体瘤 详情
LD013 CAR T-cell therapy (Nanjing Landun Biotechnology) LD013; LD-013 临床一期 南京蓝盾生物科技有限公司 卵巢癌, 实体瘤 详情
RD-138 RD-138 临床一期 南京驯鹿生物技术股份有限公司 多发性骨髓瘤 详情
RD-133 RD133 临床一期 南京驯鹿生物技术股份有限公司 实体瘤, 肿瘤 详情
PM-3006 PM-3006 临床一期 普米斯生物技术(珠海)有限公司 详情
Autologous Mesothelin-specific TCR-T Cell Therapy (Lonza Walkersville) 临床一期 弗莱德哈钦森癌症研究中心 胰腺癌, 胰腺导管癌 详情
Anti-mesothelin CAR-NK cell therapy(Guojianchengnuo) ALF-101 临床一期 国健亦诺生物科技(北京)有限公司 卵巢上皮癌 详情
Inezetamab AMG-994 临床一期 安进 实体瘤 详情
αPD1-MSLN-CAR T cell therapy (Shanghai Cell Therapy Group Co.,Ltd) BZDS1901; BZDS-1901; BZD1901 临床一期 上海细胞治疗集团有限公司 卵巢癌, 实体瘤, 间皮组织肿瘤, 结直肠癌, 非小细胞肺癌 详情
KD-021 KD-021 临床一期 南京凯地生物科技有限公司 肿瘤 详情
Anti-mesothelin CAR-T (Pregene) 临床阶段不明 普瑞金(深圳)生物技术有限公司 胸水 详情
TCR-like CAR-T Cell Therapy(Zhongda Hospital Southeast University) Zhongda Hospital Southeast University 详情
Mesothelin-CAR-T Cells(Fapon Biopharma) FP-002 菲鹏生物股份有限公司 详情

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