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HGF信息

英文名称:Hepatocyte growth factor
中文名称:肝细胞生长因子
靶点别称:EC 3.4.21.7,Hepatocyte Growth Factor (Hepapoietin A; Scatter Factor),EC 3.4.21,HGF,Hepatopoietin-A,Scatter factor,Hepatocyte Growth Factor (Hepapoietin A,Scatter Factor),Fibroblast-Derived Tumor Cytotoxic Factor,Lung Fibroblast-Derived Mitogen,SF,Deafness, Autosomal Recessive 39,Hepatopoietin A,DFNB39,F-TCF,HGFB,Hepatocyte Growth Factor,HPTA
上市药物数量:1
临床药物数量:7
最高研发阶段:批准上市

HGF产品列表

ACRO质量管理体系
 
评论(10)
HGF-H52H3|Human HGF Protein, His Tag (MALS verified)
  1. 188XXXXXXX9
  2. 1人赞
  3. As a stimulating factor to activate the downstream signaling pathway, ACRO's products have great advantages in speed, and the delivery time is much shorter than that of foreign products, and the effect is good. I hope to continue to make high-quality products
  4. 2023-04-14
HGF-H52H3|Human HGF Protein, His Tag (MALS verified)
  1. 182XXXXXXX4
  2. 0人赞
  3. This product has good specificity in PK experiments, and almost does not produce non-specific binding with plasma or serum, which guarantees the reliability and accuracy of experimental data
  4. 2023-05-09
HGF-H52H3|Human HGF Protein, His Tag (MALS verified)
  1. 131XXXXXXX1
  2. 0人赞
  3. Acro家的这款抗原货期很短,下单一周内就到了,全程冷链运输,蛋白性状稳定,按照COA推荐的方式进行复溶,能获得较为稳定的实验结果。
  4. 2024-04-16
 

HGF分子别名

HGF,HPTA,SF

HGF分子背景

HGF, also known as scatter factor and hepatopoietin A, is a pleiotropic protein in the plasminogen subfamily of S1 peptidases , and acts as a growth factor for a broad spectrum of tissues and cell types. HGF signals through a transmembrane tyrosine kinase receptor known as MET. Activities of HGF include the induction of cell proliferation, motility, morphogenesis, inhibition of cell growth, and enhancement of neuron survival. HGF is a crucial mitogen for liver regeneration processes, HGF promotes the motility of cardiac stem cells in damaged myocardium.
Human and murine HGF are cross-reactive. Human HGF is expressed as a linear, polypeptide-precursor glycoprotein residues. Proteolytic processing of this precursor generates the biologically active heterodimeric form of HGF, which consists of two polypeptide chains (α-chain and β-chain) held together by a single disulfide bond resulting in formation of a biologically active heterodimer.

HGF上市药物信息

英文名称 中文名称 研发代码 研发阶段 公司 最早商品名 最早批准国家 最早适应症 最早批准公司 最早批准日期 适应症 临床试验
Beperminogene perplasmid DS-992; AMG-0001; TREAT-HGF; AMG-0001-01 批准上市 Anges Mg, 大阪大学 Collategene Japan 缺血, 外周动脉疾病 null, Anges Inc 2019-03-01 动脉闭塞性疾病, 外周血管疾病, 动脉粥样硬化, 血管疾病, 足溃疡, 缺血, 溃疡, 外周动脉疾病 详情

HGF临床药物信息

英文名称 研发代码 研发阶段 公司 适应症 临床试验
Donaperminogene seltoplasmid (ViroMed) VM202-Stent; VM202-PAD; pCK-HGF-X7; VM202-DPN; VM-202CAD; VM-202ALS; VM202-RY; VM-202; NL-003; HGF-X7 临床三期 Viromed 缺血性心脏病, 糖尿病足溃疡, 夏科-马里-图斯病, 间歇性跛行, 心肌梗塞, 动脉闭塞性疾病, 外周血管疾病, 糖尿病神经病变, 缺血, 糖尿病周围神经病变, 溃疡, 肌萎缩性侧索硬化, 外周动脉疾病 详情
Fosgonimeton ATH-1017; NDX-1017 临床三期 M3 Biotechnology 阿尔茨海默病, 路易氏体型失智症 详情
Ficlatuzumab AV-299; SCH-900105 临床三期 Aveo 多发性骨髓瘤, 非小细胞肺癌, 鳞状细胞癌, 淋巴瘤, 急性髓细胞样白血病, 肺癌, 口咽肿瘤, 胆管上皮癌, 呼吸道肿瘤, 实体瘤, 结肠癌, 胰腺癌, 小细胞肺癌, 胶质母细胞瘤, 头颈部鳞状细胞癌, 基底细胞癌, 头颈癌, 肝癌 详情
MP-0250 MP-0250 临床二期 Molecular Partners Ag 肿瘤, 多发性骨髓瘤, 非小细胞肺癌 详情
YYB-101 NOV-1105; YYB-101 临床二期 Yooyoung 实体瘤, 结直肠癌 详情
ATH-1020 ATH-1020 临床一期 Athira Pharma Inc 详情
Microbiome-optimized autologous stem cell therapy (Biotech Holdings) 临床阶段不明 Biotech Holdings 外周血管疾病 详情

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