新冠疫苗研发核心工具 - ACROBiosystems百普赛斯生物科技股份有限公司

2019年12月，一种新型的冠状病毒SARS-CoV-2开始在全球范围内快速传播，造成了全球性的新冠疫情大流行，导致（截止到2021年11月）超过2亿人确诊感染新型冠状病毒，近500万人死亡，给全球人民的生命健康带来巨大威胁的同时，对世界各国的社会稳定和经济发展造成了深远的影响。

不仅如此，在新冠疫情肆虐全球的过程中，不断出现的新冠病毒变异毒株更是使得挑战升级。目前，世界卫生组织（WHO）已将具有更强传播能力或免疫逃逸能力的4种变异毒株列为“需要特别关注的突变毒株”（VOCs），包括Alpha（B.1.1.7）、Beta（B.1.351）、Gamma（P.1）及Delta（B.1.617.2）。其中，Beta和Gamma毒株具有极强的免疫逃逸能力，而Alpha和Delta变异毒株具有极强的传播能力和较强的免疫逃逸能力。目前，在Delta变异毒株逐渐成为全球主要流行毒株的同时，如Lambda（C.37）、Mu（B.1.621）、C.1.2的新型变异毒株也不断涌现。

>>> 点击查看新冠突变抗原蛋白及相关产品

面对来势汹汹的新冠疫情，疫苗作为防控传染病最有效且最经济的公共健康措施之一，开发可高效预防新型冠状病毒感染及传播的疫苗并持续评估其对流行突变株的有效性具有重要意义。

新冠疫苗研发技术路线

在疫情爆发后仅1年多的时间里，全球各科研单位和疫苗公司紧密合作、共同努力，成功研制出包括灭活病毒疫苗、重组蛋白疫苗、腺病毒载体疫苗、mRNA疫苗等多款新冠疫苗并获得紧急使用授权，在全球范围内进行接种。另据不完全统计，目前全球共有300余种新冠候选疫苗处于临床前及临床阶段试验，接下来仍将有多种新冠疫苗获批使用。

新冠疫苗技术路线

重组亚单位疫苗

核酸疫苗

病毒载体疫苗

完整病毒疫苗

新冠疫苗研发生产和临床的法规要求

国家药品监督管理局药品审评中心于2020年8月发布了一系列《新型冠状病毒预防用疫苗研发技术指导原则（试行）》，从药学研究、非临床研究到临床研究全流程，明确了灭活疫苗、基因工程重组疫苗、病毒载体类疫苗、DNA疫苗及mRNA疫苗等不同技术路线评价过程中的关键指标。

新冠疫苗开发流程

生产/质量控制

(1)疫苗抗原含量检测

灭活疫苗/重组蛋白疫苗：SDS-PAGE，MS，ELISA；

病毒载体疫苗/核酸疫苗：Western Blot，FACS；

(2)疫苗抗原活性检测

重组蛋白疫苗：ELISA，SPR，BLI

(3)疫苗生物效价检测

动物血清总抗体检测：间接法ELISA

临床前药效学研究

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ动物血清总抗体检测：间接法ELISA

Ⅱ动物血清中和抗体检测：cVNT，pVNT，sVNT（竞争法ELISA）

★细胞免疫:Elispot

②体外效价检测: 疫苗抗原含量：双抗夹心ELISA

③动物保护性试验:动物攻毒保护试验

(2)毒理研究

①体液免疫（抗体亚型检测）：间接法ELISA

②细胞免疫（特异性T细胞及细胞因子检测）：Elispot

早期临床试验（I-II期）

关键性注册临床试验（III期）

(1)疫苗生物效价研究

①体内效力试验:

★体液免疫:

Ⅰ人体血清总抗体检测：间接法ELISA

Ⅱ人体血清中和抗体检测：cVNT，pVNT，sVNT（竞争法ELISA）

★细胞免疫:Elispot

②体外效价检测:

★疫苗抗原含量:双抗夹心法ELISA

③动物保护性试验：动物攻毒保护试验

(2)毒理研究

①体液免疫（抗体亚型检测）：间接法ELISA

②细胞免疫（特异性T细胞及细胞因子检测）：Elispot

(3) 免疫持久性 (III期临床试验)

①人体血清总抗体检测：间接法ELISA

②人体血清中和抗体检测:CVNT， pVNT， sVNT(竞争法ELISA)

>>> 点击下载《新型冠状病毒预防用疫苗研发技术指导原则（试行）》系列指导原则

疫苗研发与临床及临床前研究解决方案

为助力新冠疫苗研发，加速疫苗上市进程，ACROBiosystems（百普赛斯）持续关注新冠疫情发展，开发了针对新冠野生型及Alpha (B.1.1.7)、Beta (B.1.351)、Gamma (P.1)、Delta (B.1.617.2)、Lambda (C.37)、Mu (B.1.621)等VOCs及VOIs流行突变株的系列相关产品，提供高纯度高稳定性的抗原、高活性广谱抗体、突变特异性ELISA试剂盒及高效便捷的预偶联磁珠产品，力求为新冠疫苗研发到上市前的全流程提供相应解决方案。

疫苗抗原含量检测

天然Pre-fusion状态三聚体Spike蛋白
RBD/S trimer抗原定量检测试剂盒
突变特异性抗体

SDS-PAGE及MS抗原检测的高纯度标品——天然Pre-fusion状态三聚体Spike蛋白

引入6P突变使Spike蛋白稳定在融合前构象，接近蛋白天然构象
经SDS-PAGE和SEC-MALS及负染电镜技术验证，Spike三聚体纯度>90%
提供所有VOCs及其他热门突变株产品，突变位点与真实毒株一致

产品列表

新冠种属	货号	突变位点	标签	订购/预购
Omicron \| XBB.1.16	SPN-C524s	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, E180V, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478R, E484A, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| XBB.2.3	SPN-C524t	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, P521S, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| DS.1	SPN-C524r	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, R403K, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| XBB.1.5	SPN-C524i	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| XBB.1.5	SPN-C82Ez	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486P, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BQ.1.1.10	SPN-C524m	T19I, LPP24-26del, A27S, HV69-70del, G142D, Y144del, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BQ.1.1.11	SPN-C524l	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, S494P, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BN.1	SPN-C524b	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, K356T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| CH.1.1	SPN-C5249	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| CH.1.1	SPN-C82Q0	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, G446S, L452R, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| XBB	SPN-C522w	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, K356T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
	SPN-C5248	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
	SPN-C82Ew	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BQ.1	SPN-C524a	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BJ.1	SPN-C522u	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, S477N, T478K, V483A, E484A, F490V, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, G798D, Q954H, N969K, S1003I, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| XBB.1	SPN-C522t	T19I, LPP24-26del, A27S, V83A, G142D, Y144del, H146Q, Q183E, V213E, G252V, G339H, R346T, L368I, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, V445P, G446S, N460K, S477N, T478K, E484A, F486S, F490S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BQ.1.1	SPN-C522s	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BQ.1.1	SPN-C82Ey	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444T, L452R, N460K, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.2.75.2	SPN-C522r	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.75.2	SPN-C82Ex	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, F486S, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, D1199N, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BF.7	SPN-C522q	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BF.7	SPN-C82Ev	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.5.5	SPN-C522p	T19I, LPP24-26del, A27S, HV69-70del, T76I, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.3.20	SPN-C522n	T19I, LPP24-26del, A27S, G142D, M153T, N164K, V213G, H245N, G257D, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, K444R, N450D, L452M, N460K, S477N, T478K, E484R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.4.6	SPN-C522m	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.75	SPN-C522f	T19I, LPP24-26del, A27S, G142D, K147E, W152R, F157L, I210V, V213G, G257S, G339H, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, G446S, N460K, S477N, T478K, E484A, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.76	SPN-C522i	T19I, LPP24-26del, A27S, G142D, V213G, Y248N, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.74	SPN-C522h	T19I, LPP24-26del, A27S, G142D, V213G, G339D, R346T, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452M, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.38	SPN-C522g	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417T, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.5	SPN-C522e	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.5	SPN-C82Eu	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.4	SPN-C5229	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.4	SPN-C82Et	T19I, LPP24-26del, A27S, HV69-70del, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452R, S477N, T478K, E484A, F486V, Q498R, N501Y, Y505H, D614G, H655Y, N658S, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.2.12.1	SPN-C522d	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2.12.1	SPN-C82Es	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452Q, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, S704L, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.2.13	SPN-C5227	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, L452M, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
XD \| BA.1 x AY.4 recombinant	SPN-C5226	T19R, A27S, T95I, G142D, EFR156G, NL211I, INS214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.3	SPN-C5225	A67V, H69del, V70del, T95I, G142D, V143del, Y144del, Y145del, N211del, L212I, G339D, S371F, S373P, S375F, D405N, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2	SPN-C5223	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| BA.2	SPN-C82Er	T19I, LPP24-26del, A27S, G142D, V213G, G339D, S371F, S373P, S375F, T376A, D405N, R408S, K417N, N440K, S477N, T478K, E484A, Q493R, Q498R, N501Y, Y505H, D614G, H655Y, N679K, P681H, N764K, D796Y, Q954H, N969K, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag & Avi Tag	订购
Omicron \| BA.1.1	SPN-C5224	A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, R346K, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F, R683A, R685A, F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
Omicron \| B.1.1.529	SPN-C82Ee	A67V, HV69-70del, T95I, G142D, VYY143-145del, N211del, L212I, ins214EPE, G339D, S371L, S373P, S375F, K417N, N440K, G446S, S477N, T478K, E484A, Q493R, G496S, Q498R, N501Y, Y505H, T547K, D614G, H655Y, N679K, P681H, N764K, D796Y, N856K, Q954H, N969K, L981F	His Tag & Avi Tag	订购
Delta Plus \| AY.4.2	SPN-C52Hu	T19R, T95I, Y145H, EF156-157del, R158G, A222V, L452R, T478K, D614G, P681R, D950N	His Tag	订购
Delta Plus \| AY.1\|AY.2\|AY.3	SPN-C52Ht	T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N	His Tag	订购
Delta Plus \| AY.1\|AY.2\|AY.3	SPN-C82Ei	T19R, V70F, FR157-158Del, A222V, W258L, K417N, L452R, T478K, D614G, P681R, D950N	His Tag & Avi Tag	订购
Delta \| B.1.617.2	SPN-C52He	T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N	His Tag	订购
Delta \| B.1.617.2	SPN-C82Ec	T19R, G142D, EF156-157del, R158G, L452R, T478K, D614G, P681R, D950N	His Tag & Avi Tag	订购
Gamma \| P.1	SPN-C52Hg	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F	His Tag	订购
Gamma \| P.1	SPN-C82E6	L18F, T20N, P26S, D138Y, R190S, K417T, E484K, N501Y, D614G, H655Y, T1027I, V1176F	His Tag & Avi Tag	订购
Beta \| B.1.351	SPN-C52Hk	L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G, A701V	His Tag	订购
	SPN-C52Hp	N501Y, D614G	His Tag	订购
	SPN-C82E4	L18F, D80A, D215G, LAL242-244del, R246I, K417N, E484K, N501Y, D614G, A701V	His Tag & Avi Tag	订购
Alpha \| B.1.1.7	SPN-C52H6	HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H	His Tag	订购
Alpha \| B.1.1.7	SPN-C82E5	HV69-70del, Y144del, N501Y, A570D, D614G, P681H, T716I, S982A, D1118H	His Tag & Avi Tag	订购
C.1.2	SPN-C52Hb	C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N	His Tag	订购
C.1.2	SPN-C82Eq	C136F, Y144del, R190S, D215G, LA242-243del, Y449H, E484K, N501Y, D614G, H655Y, N679K, T716I, T859N	His Tag & Avi Tag	订购
Mu \| B.1.621	SPN-C52Ha	T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N	His Tag	订购
Mu \| B.1.621	SPN-C82Ek	T95I, Y144S, Y145N, R346K, E484K, N501Y, D614G, P681H, D950N	His Tag & Avi Tag	订购
Lambda \| C.37	SPN-C52Hs	G75V, T76I, SYLTPGD 247-253 del, L452Q, F490S, D614G, T859N	His Tag	订购
Kappa \| B.1.617.1	SPN-C52Hr	T95I, G142D, E154K, L452R, E484Q, D614G, P681R	His Tag	订购
B.1.620	SPN-C82Ed	P26S, HV69-70del, V126A, Y144del, LLA241-243del, H245Y, S477N, E484K, D614G, P681H, T1027I, D1118H	His Tag & Avi Tag	订购
D614G	SPN-C52H3	D614G	His Tag	订购
D614G	SPN-C82E3	D614G	His Tag & Avi Tag	订购
Wild type	SPN-C52H9		His Tag	订购
	SPN-C52Hd	F817P, A892P, A899P, A942P, K986P, V987P	His Tag	订购
	SPN-C82E9		His Tag & Avi Tag	订购

验证数据

结构鉴定数据（SDS-PAGE & SEC-MALS & 负染电镜）

The purity of SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) is more than 90% verified by SDS-PAGE under reducing (R) condition. The molecular weight was around 550-660 kDa confirmed by SEC-MALS. The particles are similar in size and appearance to SARS-CoV-2 trimers reported in published literature verified by negative stain electron micrography.

Protocol

活性验证数据

Immobilized Anti-SARS-CoV-2 Neutralizing Antibody, Human IgG1 (Cat. No. SAD-S35) at 1 μg/mL (100 μL/well) can bind SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9) with a linear range of 0.3-10 ng/mL.

Protocol

活性验证数据

用不同的SARS-CoV-2 S protein检测康复病人血清，其中SARS-CoV-2 S protein, His Tag, Super stable trimer (Cat. No. SPN-C52H9)信噪比较高。

Protocol

高效获取抗原含量指标——RBD/S trimer抗原定量检测试剂盒（双抗体夹心法ELISA）

满足各种疫苗对于不同灵敏度需求的检测
试剂盒中抗体对可识别不同突变株抗原且活性不变
经客户验证，实验数据稳定，可对疫苗量产进行定量监控

产品列表

货号	产品描述	订购/预购
RAS-A010	SARS-CoV-2 Nucleocapsid Protein Titer Assay Kit	订购
RAS-A117	SARS-CoV-2 Spike RBD (BA.4 & BA.5) ELISA Kit	订购
RAS-A149	SARS-CoV-2 Spike Trimer (XBB.1) ELISA Kit (For Vaccine Development)	订购
RAS-A145	SARS-CoV-2 Spike Trimer (XBB.1.5) ELISA Kit (For Vaccine Development)	订购
RAS-A146	SARS-CoV-2 Spike RBD (XBB.1.5) ELISA Kit (For Vaccine Development)	订购

验证数据

试剂盒检测Spike Protein定量范围：781-3.05pg/mL

试剂盒检测Spike Protein定量范围：625-4.88ng/mL

突变抗原含量检测方法建立必备试剂——Omicron/Delta/Beta & Gamma突变特异性抗体

特异性：经ELISA验证，该抗体与只相应突变RBD抗原特异性结合，与其他野生型或突变抗原不结合
高活性：抗体与抗原结合活性经BLI/SPR验证
高纯度：抗体纯度经SDS-PAGE验证>95%，经MALS验证>90%
可用于针对Omicron变异株的二代疫苗的研发、生产质控、临床前及临床研究中的免疫原性检测实验

产品列表

货号	种属	产品描述	抗原表位	订购/预购

验证数据

>经BLI检测，SPD-M305可以与Omicron突变Spike RBD (Cat.No. SPD-C522e)结合，亲和力常数为9.07 nM。

Loaded Monoclonal Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1 (Cat. No. SPD-M305) on AMC Biosensor, can bind SARS-CoV-2 Spike RBD, His Tag (B.1.1.529/Omicron) (Cat. No. SPD-C522e) with an affinity constant of 9.07 nM as determined in BLI assay (ForteBio Octet Red96e).

Protocol

>经ELISA验证，SPD-M305可以与Omicron突变Spike RBD (Cat.No. SPD-C522e)结合，线性范围0.4- 12.5ng/mL；与野生型(Cat.No. SPD-C52H1)、Alpha (Cat.No. SPD-C52Hn)、Beta(Cat.No. SPD-C52Hp)、Delta(Cat.No. SPD-C52Hh)、Gamma(Cat.No. SPD-C52Hr) 的 Spike RBD均不结合。

Immobilized SARS-CoV-2 Spike RBD (Omicron, Cat.No. SPD-C522e) can bind Anti-SARS-CoV-2 Spike RBD Antibody, Mouse IgG1(Cat.No.SPD-M305) with linear range of 0.4-12.5 ng/mL. The antibody does not bind Spike RBD of WT (Cat.No. SPD-C52H1), Alpha (Cat.No. SPD-C52Hn), Beta (Cat.No. SPD-C52Hp), Delta(Cat.No. SPD-C52Hh) and Gamma (Cat.No. SPD-C52Hr).

Protocol

疫苗抗原活性检测

高质量ACE2受体蛋白
抗原与ACE2亲和力服务

抗原活性验证天然二聚体配体——高质量ACE2受体蛋白

提供His、His, Avitag™、Fc、Fc, Avitag™等不同标签
覆盖Human、Mouse、Cynomolgus、Rat、Paguma larvata不同种属
生物素化及非生物素化受体蛋白可选择
高纯度高结合活性经验证

产品列表

分子	货号	种属	标签	宿主	产品描述	订购/预购
ACE2	AC2-H82E6	Human	His Tag & Avi Tag	HEK293	Biotinylated Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)	订购
ACE2	AC2-H82E8	Human	His Tag & Avi Tag	HEK293	Biotinylated Monomeric Human ACE2 / ACEH Protein, His,Avitag™ (MALS verified)	订购
ACE2	AC2-H52H8	Human	His Tag	HEK293	Human ACE2 / ACEH Protein, His Tag (MALS verified)	订购
ACE2	AC2-HP2H3	Human	His Tag	HEK293	PE-Labeled Human ACE2 / ACEH Protein, His TagStar Staining	订购
ACE2	AC2-H5257	Human	Fc Tag	HEK293	Human ACE2 / ACEH Protein, Fc Tag (MALS verified)	订购
ACE2	AC2-H82F9	Human	Fc Tag & Avi Tag	HEK293	Biotinylated Human ACE2 / ACEH Protein, Fc,Avitag™	订购
ACE2	AC2-H5205	Human	Mouse IgG Fc Tag	HEK293	Human ACE2 / ACEH Protein, Mouse IgG1 Fc Tag (MALS verified)	订购
ACE2	AC2-M5248	Mouse	His Tag	HEK293	Mouse ACE2 / ACEH Protein, His Tag (MALS verified)	订购
ACE2	AC2-C52H7	Cynomolgus	His Tag	HEK293	Cynomolgus ACE2 / ACEH Protein, His Tag	订购
ACE2	AC2-R5246	Rat	His Tag	HEK293	Rat ACE2 / ACEH Protein, His Tag (MALS verified)	订购
ACE2	AC2-P5248	Paguma larvata	His Tag	HEK293	Paguma larvata ACE2 / ACEH Protein, His Tag (SPR verified)	订购
ACE2	AC2-M52H3	Mink	His Tag	HEK293	Mink ACE2 / ACEH Protein, His Tag (MALS verified)	订购

验证数据

活性验证数据

Immobilized SARS-CoV-2 S1 protein, His Tag (Cat. No. S1N-C52H3) at 2 μg/mL (100 μL/well) can bind Biotinylated Human ACE2, His,Avitag (Cat. No. AC2-H82E6) with a linear range of 2-20 ng/mL (QC tested).

Protocol

Human ACE2, Fc Tag (Cat. No. AC2-H5257) captured on CM5 chip via Anti-human IgG Fc antibodies surface can bind recombinant SARS-CoV-2 Spike vaccine with an affinity constant of 16.9 nM as determined in a SPR assay (Biacore T200).

Protocol

输出疫苗抗原与ACE2结合的全面性研究——抗原与ACE2亲和力服务

可进行疫苗抗原与ACE2结合的快慢、强弱及机理等多方面的定量和定性的全面分析
提供多种优质抗原蛋白及不同验证方法（SPR、BLI等）
高标准的质量管理控制体系，数据质量满足申报要求
个性化方案及报告形式定制，最快次日即可出具报告
提供多地多平台检测服务

生物效价&免疫持久性检测

抗体滴度检测
中和抗体滴度检测
基于流式细胞术的多突变联合检测
新冠Spike蛋白萤光素酶假病毒
广谱RBD蛋白中和抗体

满足疫苗开发各阶段(动物 & 人体)体内效价检测需求——S trimer/RBD/S1 IgG抗体滴度检测试剂盒(间接法ELISA)

可溯源至WHO国际标准血清 (G, NIBSC code 20/136)，试剂盒标品与其相关性良好，检测数据具有实验室间可比性和标准性
提供适用于人、鼠、猴等不同种属血清抗体检测的试剂盒，满足临床前及临床实验需求
提供VOCs突变特异性IgG抗体滴度试剂盒，可用于疫苗针对突变的临床及临床前效价检测
试剂批间差小，试剂稳定

临床前实验
临床实验

货号	预包被抗原	产品描述	订购/预购
RAS-T141	Spike Trimer	Mouse Anti-SARS-CoV-2 (XBB.1.5) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购
RAS-T142	Spike RBD	Mouse Anti-SARS-CoV-2 (XBB.1.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	订购
RAS-T143	Spike Trimer	Mouse Anti-SARS-CoV-2 (BQ.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	预购
RAS-T148	Spike Trimer	Mouse Anti-SARS-CoV-2 (XBB.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购
RAS-T144	Spike RBD	Mouse Anti-SARS-CoV-2 (BQ.1.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	预购
RAS-T136	Spike RBD	Monkey Anti-SARS-CoV-2 (BA.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	订购
RAS-T113	Spike RBD	Mouse Anti-SARS-CoV-2 (BA.2.12.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	订购
RAS-T064	Spike S1	Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike S1)	预购
RAS-T062	Spike RBD	Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	预购
RAS-T063	Spike protein	Monkey Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	预购
RAS-T070	Spike protein	Mouse Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购

货号	预包被抗原	产品描述	订购/预购
RAS-T137	Spike Trimer	Human Anti-SARS-CoV-2 (XBB.1.5) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购
RAS-T138	Spike RBD	Human Anti-SARS-CoV-2 (XBB.1.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	订购
RAS-T139	Spike Trimer	Human Anti-SARS-CoV-2 (BQ.1) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	预购
RAS-T140	Spike RBD	Human Anti-SARS-CoV-2 (BQ.1.1) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	预购
RAS-T134	Spike RBD	Human Anti-SARS-CoV-2 (BA.5) Antibody IgG Titer Serologic Assay Kit (Spike RBD)	订购
RAS-T043	Spike Trimer	Anti-SARS-CoV-2 (B.1.617.2) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购
RAS-T027	Spike protein	Anti-SARS-CoV-2 (B.1.1.7) Antibody IgG Titer Serologic Assay Kit (Spike Trimer)	订购
RAS-T049	Spike RBD	Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike RBD)	订购
RAS-T048	Spike protein	Anti-SARS-CoV-2 Antibody IgG Quantitative Detection Kit (Spike Trimer)	订购

验证数据

检测示例数据

接种疫苗后的血清用新冠抗体滴度检测试剂盒（Cat.No.RAS-T024）进行验证,可准确测试血清中抗体滴度。经检测，试剂盒批间精密度<10%，批内精密度：<15%。

Protocol

WHO血清标定结果

Protocol

经WHO国际标准血清(G,NIBSC code 20/136 )标定的试剂盒 (Cat.No. RAS-T048 )可用于新冠疫苗接种后血清样本中的IgG抗体的定量检测等，能够显著提高相关指标检测的效率和准确度，是对现有方式的重要补充。

Protocol

便捷高通量中和抗体检测替代方案——特异性中和抗体滴度试剂盒（竞争法ELISA）

可溯源至WHO国际标准血清 (G, NIBSC code 20/136)，试剂盒标品与其相关性良好，
检测数据具有实验室间可比性和标准性
与假病毒检测结果相关性好，可作为假病毒中和活性检测的高通量替代方法
操作简单，实验仅需1.5-2h，可同时检测90+样本
提供突变（VOCs）特异性中和抗体检测试剂盒产品，可特异性识别不同突变

新冠突变	货号	产品描述	订购/预购
Wild type	RAS-N044	Anti-SARS-CoV-2 Neutralizing Antibody Quantitative Detection Kit (Spike RBD)	订购
Alpha \| B.1.1.7	RAS-N028	Anti-SARS-CoV-2 (B.1.1.7) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)	订购
Beta \| B.1.351	RAS-N031	Anti-SARS-CoV-2 (B.1.351) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)	订购
Gamma \| P.1	RAS-N034	Anti-SARS-CoV-2 (P.1) Neutralizing Antibody Titer Serologic Assay Kit (Spike RBD)	订购
Delta \| B.1.617.2	RAS-N041	Anti-SARS-CoV-2 (B.1.617.2) Neutralizing Antibody Titer Serologic Assay Kit (Spike Trimer)	订购

验证数据

实验原理

竞争ELISA法

临床检测数据

接种疫苗后血清验证实验结果表明试剂盒(Cat. No. RAS-N022)对血清样本检测特异性好，准确度高。

假病毒验证

利用RAS-N022试剂盒与假病毒实验对16例康复病人的血清进行中和抗体检测。数据显示，两者具有很高的相关性(R² =93.73)。

突变特异性结果

56例接种新冠灭活疫苗后血清，用野生型与突变中和抗体检测试剂盒进行检测，Alpha，Beta，Gamma，Delta检测结果均略有降低，其中Beta，Gamma降低较明显。

WHO血清标定结果

注：y = (A - D) / [1 + (x/C)^B] + D (A =1.55562 B =1.45522 C=14.42024 D=0.05532 r^2= 1)

少量样本一次性多变异株效价快速评价工具——基于流式细胞术的多因子联合检测试剂盒

创新基于流式细胞术全面覆盖野生型及五个VOC毒株(含Omicron)，一次实验完成全球主流变异株检测；
提供不同Mouse、Monkey、Human不同种属产品，满足临床前到临床不同阶段实验需求；
同步性好，便于对各突变株结合抗体横向对比，减少不同实验产生的实验误差；
检测样本用量低，仅需5ul样本即可高通量完成多突变株结合/中和抗体检测；
检测时间短，2.5h内即可完成一次检测，支持一个工作日内重复实验；
经济高效，同等实验相比其他方法节约试剂成本6倍以上；
仪器适应性强，可与不同商家品牌流式细胞仪配套使用；
基于自主蛋白原料开发，产品性能和供货能力保障。

抗体滴度检测金标准必须的关键试剂——新冠Spike蛋白萤光素酶假病毒

病毒原液感染细胞后萤光可达10^6 RLU
不具有复制能力，无致病性
权威性、高灵敏度的中和滴度检测方法
适用于抗体蛋白、血清等的中和效价检测，抑制率可达99%以上

货号	产品描述	订购/预购

真正合格的中和抗体检测质控品——广谱RBD蛋白中和抗体

具备广谱中和活性，可有效中和多种主流突变株
经ELISA验证，特异性及结合活性良好
经假病毒实验验证，对所有VOCs突变株具有广谱中和活性

产品列表

货号	种属	产品描述	抗原表位	订购/预购
SPD-M121	Mouse	Anti-SARS-CoV-2 Spike NTD Antibody, Chimeric mAb, Human IgG1 (AM121)	Spike NTD	订购
SAD-S35	Human	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Human IgG1 (AS35)	Spike RBD	订购
SPD-M180	Human	Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Human IgG1 (AM180)	Spike RBD	订购
SPD-M265	Human	Anti-SARS-CoV-2 Spike RBD Broadly Neutralizing Antibody, Human IgG1 (AM359b) (MALS verified)	Spike RBD	订购
S1N-M122	Mouse	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122)	Spike RBD	订购
S1N-VM226	Mouse	Biotinylated Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (MALS verified)	Spike RBD	订购
SCT-M369	Mouse	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Mouse IgG1 (AM122)	Spike RBD	订购
SPD-M128	Mouse	Anti-SARS-CoV-2 RBD Potent Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM128)	Spike RBD	订购
SPD-M162	Mouse	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgM (AM122)	Spike RBD	订购
SPD-M58P1	Mouse	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgA1 (AM122)	Spike RBD	订购
SPD-PM226	Mouse	PE-Labeled Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Human IgG1 (AM122) (Site-specific conjugation)	Spike RBD	订购
SPD-M201	Cynomolgus	Anti-SARS-CoV-2 Spike RBD Neutralizing Antibody, Chimeric mAb, Cynomolgus IgG1 (AM122)	Spike RBD	订购

验证数据

>ELISA验证数据

Anti-SARS-CoV-2 Spike RBD Neutralizing antibody (Cat.No.S1N-M122)neutralizes SARS-CoV-2 Spike RBD by inhibiting RBD: ACE2 interaction. The ACE2-coated plate is incubated with the wild type (WT) RBD or B.1.1.7, B.1.351, P.1, B.1.617.1, B.1.617.2 mutant and treated with the neutralizing antibody at increasing concentration. Percent inhibition is calculated based on the OD value.

Protocol

>ELISA验证数据

经假病毒实验体系验证，广谱型中和抗体(Cat.No.S1N-M122) 可以有效中和野生型及Alpha/Beta/Gamma/Delta突变株病毒，适合作为质控品，应用于针对突变株的中和抗体筛选、重组蛋白疫苗临床前及临床研究中的效价检测、血清中的中和抗体检测等。

Protocol

>>> 相关抗体产品活性经假病毒验证，点击查看详情。

>>> 点击查看更多SARS-CoV-2结合抗体、IgG抗体亚型及检测二抗

毒理研究

抗体亚型检测试剂盒

快速获取ADE、VED研究关键结果——便捷高通量IgG抗体亚型检测试剂盒（间接法ELISA）

提供IgG1、IgG2、IgG3、IgG4不同亚型血清学检测用试剂盒
特异性好，可正确分型
产品稳定性及批间一致性良好
组分配套齐全，操作简单，可同时检测90+样本

新冠突变	货号	产品描述	订购/预购
Wild type	RAS-T014	Anti-SARS-CoV-2 Antibody IgG1 Titer Serologic Assay Kit	订购
Wild type	RAS-T015	Anti-SARS-CoV-2 Antibody IgG2 Titer Serologic Assay Kit	订购
Wild type	RAS-T016	Anti-SARS-CoV-2 Antibody IgG3 Titer Serologic Assay Kit	订购
Wild type	RAS-T017	Anti-SARS-CoV-2 Antibody IgG4 Titer Serologic Assay Kit	订购
Omicron \| B.1.1.529	RAS-T066	Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG2 Titer Serologic Assay Kit (Spike RBD)	预购
Omicron \| B.1.1.529	RAS-T067	Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG3 Titer Serologic Assay Kit (Spike RBD)	订购
Omicron \| B.1.1.529	RAS-T068	Anti-SARS-CoV-2 (B.1.1.529) Antibody IgG4 Titer Serologic Assay Kit (Spike RBD)	预购

验证数据

Cross-validation data for antibody subtype detection

>>> 如果您希望ACRO开发更多类型的SARS-CoV-2(COVID-19)的产品或有定制化的产品、服务需求，请点击提议

新冠疫苗生物效价评价整体解决方案

ACROBiosystems致力于为广大医药研发领域客户提供一个更简便快速的开发过程，在加速开发试剂产品的同时，也希望通过我司丰富的技术服务经验加速抗疫制品研发进程。ACROBiosystems现推出新冠疫苗生物效价评价整体解决方案，提供抗原定量检测服务（ELISA）、临床前/临床总抗体/中和抗体滴度检测服务（ELISA）、假病毒中和抗体检测服务以及抗体亚型检测服务，希望通过多快好省超值技术服务，助力新冠疫苗研发生产！

点此联系我们

ACRO蛋白产品助力新冠相关研究

ACROBiosystems致力于提供靶向治疗药物研发和诊断试剂盒开发过程中所需的靶点抗原、抗体及其他关键试剂和相关服务。针对新冠病毒开发的相关蛋白产品具有纯度高、批间差小的特点，产品经过严格的体外验证、细胞活性验证和假病毒验证，可应用于新冠病毒诊断、疫苗和治疗性抗体的各个阶段。已有多个课题组将ACROBiosystems蛋白产品应用于其新冠病毒相关的研究中，相关成果发表于Cell、Nature、Science等期刊。

Orthogonal immunoassays for IgG antibodies to SARS-CoV-2 antigens reveal that immune response lasts beyond 4 mo post illness onset

Authors: Sasisekharan, Varun et al.

Journal: Proc Natl Acad Sci U S A 2021

Cited Product: SPD-C52H3 ,NUN-C5227

Application: ELISA

Request for Full-text
High affinity nanobodies block SARS-CoV-2 spike receptor binding domain interaction with human angiotensin converting enzyme

Authors: Esparza, Thomas J et al.

Journal: Scientific reports 2020

Cited Product: S1N-C5255,AC2-H52H8,SPD-C52H3,SPD-C52H3, SPD-C82E9,AC2-H82E6,SPD-S52H7,SPD-S52H4

Application: Immunization, Competitive Immunopanning, SPR & Binding Assay & Phage Display Clone Screening, BLI, Binding Assay

Request for Full-text
Antibody Signature Induced by SARS-CoV-2 Spike Protein Immunogens in Rabbits

Authors: Ravichandran S, Coyle EM, Klenow L, et al.

Journal: Sci Transl Med 2020

Cited Product: AC2-H52H8

Application: SPR

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Antibody-like proteins that capture and neutralize SARS-CoV-2

Authors: Kondo T, Iwatani Y, Matsuoka K, et al.

Journal: Science advances 2020

Cited Product: S1N-S52H5

Application: ELISA

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Binding of the SARS-CoV-2 Spike Protein to Glycans

Authors: Wei Hao,et al

Journal: BioRxiv (preprint) 2020

Cited Product: S1N-C52H3

Application: glycan microarray

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Cross-neutralization antibodies against SARS-CoV-2 and RBD mutations from convalescent patient antibody libraries

Authors: Yan Lou. et al

Journal: BioRxiv (preprint) 2020

Cited Product: SPD-S52H4,SPD-S52H7,SPD-S52H8

Application: BLI,ELISA

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Deep mutational scanning of SARS-CoV-2 receptor binding domain reveals constraints on folding and ACE2 binding

Authors: Tyler N Starr, Allison J Greaney , Sarah K Hilton, et al.

Journal: BioRxiv (preprint) 2020

Cited Product: AC2-H82E6

Application: Flow cytometry

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Flow-Mediated Susceptibility and Molecular Response of Cerebral Endothelia to SARS-CoV-2 Infection

Authors: Kaneko N, Satta S, Komuro Y, et al.

Journal: Stroke 2020

Cited Product: S1N-C82E8

Application: ELISA

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HDL-scavenger receptor B type 1 facilitates SARS-CoV-2 entry

Authors: Wei C, Wan L, Yan Q, et al.

Journal: Nature metabolism 2020

Cited Product: SPN-C52H9,S1N-C52H3,S2N-C52H5,SPD-C52H3

Application: SPR & FACS & Confocal microscopy

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Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein

Authors: Ropa, James et al.

Journal: Stem cell reviews and reports 2020

Cited Product: SPN-C52H8（该产品已下线。我们有质量更优的相似产品 SPN-C52H9 在线销售，欢迎点击了解！）

Application: Colony Forming Unit (CFU)

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Immune responses to SARS-CoV-2 in three children of parents with symptomatic COVID-19

Authors: Tosif S, Neeland MR, Sutton P, et al.

Journal: Nature communications 2020

Cited Product: S1N-S52H5,S2N-C52H5,S1N-C52H3

Application: ELISA\FACS

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Phase I/II study of COVID-19 RNA vaccine BNT162b1 in adults

Authors: Mulligan, Mark J et al.

Journal: Nature 2020

Cited Product: SPD-C82E9

Application: Immunogenicity assessments

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SARS-CoV-2 exposure, symptoms and seroprevalence in healthcare workers in Sweden

Authors: Rudberg AS, Havervall S, Månberg A, et al.

Journal: Nat Commun 2020

Cited Product: NUN-C5227

Application: Luminex

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Successful transfer of anti-SARS-CoV-2 immunity using convalescent plasma in an MM patient with hypogammaglobulinemia and COVID-19

Authors: Luetkens T, Metcalf R, Planelles V, et al.

Journal: Blood Adv 2020

Cited Product: S1N-C52H3

Application: ELISA

Request for Full-text

免疫检查点蛋白

自免疾病靶点

细胞因子靶点

GMP级别产品

细胞疗法靶点

Enzymes

全长多次跨膜蛋白

脑与神经蛋白

肿瘤微环境蛋白

信号通路蛋白

其它蛋白

免疫组化 (IHC) 抗体

抗独特型抗体

同型对照

通用型抗体

其他抗体

抗体服务

GMP级别生长因子

细胞激活

细胞培养添加剂

细胞培养基

其他产品

ELISA

qPCR试剂盒

流式细胞术

ADC 偶联试剂盒

免疫组化（IHC）试剂盒

MPCLIA

其它试剂盒

新冠病毒

水痘-带状疱疹病毒

流感病毒

疱疹病毒

呼吸道合胞病毒

狂犬病毒

其他传染病相关试剂

ViruStop检测服务

iPSC分化的即用型活体类器官

类器官分化试剂盒

类器官维持试剂盒

类器官冷冻保存试剂盒

类器官培养试剂

类器官技术服务

类器官病理检测服务

实验试剂

功能细胞株 (Cellinsight)

神经科学在体电生理实验解决方案

实验仪器设备

CAR靶点蛋白

通用型CAR检测工具

通用型蛋白

其它靶点蛋白

药物筛选与分析服务

伴随诊断

细胞培养产品

Premium(Pre-GMP) & GMP 级别原材料

基因编辑产品

大规模生产

核酸去除产品

CAR检测工具

效力测定

残留检测试剂盒 - resDetect

药代动力学研究

免疫原性研究

药效学研究

审计&申报文件支持

毒理研究

伴随诊断

药代动力学研究

免疫原性研究

毒理研究

基因编辑

AAV颗粒滴度定量检测试剂盒

伴随诊断

Premium(Pre-GMP) & GMP 级别原材料

核酸去除

基因编辑

AAV颗粒滴度定量检测试剂盒

大规模生产

残留检测 - resDetect