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GPCRs

背景
GPCRs（G-protein coupled receptors，G蛋白偶联受体）是人体中最大的膜蛋白家族，存在于体内所有的细胞中，能偶联多种配体，包括离子、神经递质、糖类、脂质、内源性多肽、蛋白酶等生物大分子，通过激活G蛋白和其他信号分子参与众多生理过程，包括肌肉收缩和松弛、神经信号传递、免疫系统调节及机体整体代谢等。GPCRs也是人体内最大的成药家族，涉及的疾病主要包括肿瘤、自身免疫、神经系统疾病、心血管疾病等，因此，GPCRs是治疗多种疾病的优秀的药物靶点。

经典的GPCRs结构示意图

GPCRs的结构
GPCRs的共同分子结构由7个跨膜α螺旋组成，这些结构域将受体分割为胞外N端，胞内C端，3个胞外环和3个胞内环。胞外环上包含有两个高度保守的半胱氨酸残基，它们可以通过形成二硫键稳定受体的空间结构。胞内环上有G蛋白结合位点。
由于GPCRs类靶点胞外露出部分有限、细胞表面表达低、蛋白聚集等因素，导致想要获得具有生物学活性的可溶性GPCRs抗原极其困难，全长结构以保证天然构象的GPCRs抗原对药物研发具有重要意义，为助力靶向GPCRs的药物研究，ACROBiosystems专门搭建了VLP, 膜蛋白-去垢剂，Nanodisc的平台化解决方案，为您提供全长GPCRs蛋白，如GPRC5D、CXCR4、CCR5、CCR8等，可用于免疫、ELISA、SPR、BLI等场景。
产品列表
  • VLP平台
  • 膜蛋白-去垢剂平台
  • Nanodisc平台
分子 货号 产品描述 订购/预购
ADORA2A ADA-H52P4 Human ADORA2A Full Length Protein (VLP)

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CCR4 CC4-H52P3 Human CCR4 Full Length Protein (VLP)

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CCR5 CC5-H52P5 Fluorescent Human CCR5 Full Length Protein (VLP)

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CCR5 CC5-H52P3 Human CCR5 Full Length Protein (VLP)

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CCR6 CC6-H52P3 Human CCR6 Full Length Protein (VLP)

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CCR7 CC7-H52P3 Human CCR7 Full Length Protein (VLP)

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CCR8 CC8-H52P4 Human CCR8 Full Length Protein (VLP)

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CGRPR & RAMP1 CG1-H52P6 Human CGRPR&RAMP1 Full Length Heterodimer Protein (VLP)

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CNR1 CN1-H52P6 Human CNR1 Full Length Protein (VLP)

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CXCR3 CX3-H52P4 Human CXCR3 Full Length Protein (VLP)

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CXCR3 CX3-M52P7 Mouse CXCR3 Full Length Protein (VLP)

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CXCR4 CX4-H5219 Human CXCR4 / CD184 Full Length Protein (VLP)

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CXCR5 CX5-H52P4 Human CXCR5 Full Length Protein (VLP)

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CXCR6 CX6-H52P3 Human CXCR6 / CD186 Full Length Protein (VLP)

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EDNRA EDA-H52P8 Human EDNRA Full Length Protein (VLP)

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EDNRB EDB-H52P7 Human EDNRB Full Length Protein (VLP)

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EDNRB EDB-HF2G4 Fluorescent Human EDNRB Full Length Protein (VLP)

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GCGR GCR-H52P5 Human GCGR / Glucagon receptor Full Length Protein (VLP)

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GPR56 GP6-H52P7 Human GPR56 Full Length Protein (VLP)

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GPR87 GP7-H52P3 Human GPR87 Full Length Protein (VLP)

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GPRC5D GPD-H52P7 Human GPRC5D Full Length Protein (VLP)

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GPRC5D GPD-HF2P7 Fluorescent Human GPRC5D Full Length Protein (VLP)

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GPRC5D GPD-M52P3 Mouse GPRC5D Full Length Protein (VLP)

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LPAR1 LP1-H52P3 Human LPAR1 Full Length Protein (VLP)

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PAR1 PA1-HF2G5 Fluorescent Human PAR1 Full Length Protein (VLP)

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PAR1 PA1-H52P6 Human PAR1 Full Length Protein (VLP)

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PAR2 PA2-H52P7 Human PAR2 Full Length Protein (VLP)

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SMO SMO-H52P3 Human SMO Full Length Protein (VLP)

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SSTR2 SS2-H5216 Human SSTR2 Full Length Protein (VLP)

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SSTR2 SS2-HF2G3 Fluorescent Human SSTR2 Full Length Protein (VLP)

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VLP VLP-N5213 Virus-Like Particle (VLP) Protein Isotype Control

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VLP VLP-NF2P4 Fluorescent Virus-Like Particle (VLP) Protein Isotype Control

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分子 货号 产品描述 订购/预购
5-HT2AR 5HR-H55D3 Human 5-HT2AR Protein (S162K, M164W, S372N), Flag,His Tag (Detergent)

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ADORA2A ADA-H52D3 Human ADORA2A Protein, Flag,His Tag (Detergent)

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ADRB2 AD2-H52D3 Human ADRB2 Protein, Flag,His Tag (Detergent)

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CCR4 CC4-H52D3 Human CCR4 Full Length Protein, Flag,His Tag (Detergent)

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CCR5 CC5-H52D1 Human CCR5 Protein, Flag,His Tag (Detergent)

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CCR5 CC5-M52D9 Mouse CCR5 Protein, Flag,His Tag (Detergent)

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CCR7 CC7-H52D3 Human CCR7 Full Length Protein, His,Flag Tag (Detergent)

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CCR8 CC8-H52D6 Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Detergent)

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CCR9 CC9-H82D3 Biotinylated Human CCR9 Protein, His,Avitag™&Flag Tag (Detergent)

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CXCR3 CX3-H52D5 Human CXCR3 Protein, Flag,His Tag (Detergent)

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CXCR5 CX5-H52D6 Human CXCR5 Protein, Flag,His Tag (Detergent)

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GCGR GCR-H52D3 Human GCGR Protein, Flag,His Tag (Detergent)

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GLP1R GLR-H52D4 Human GLP1R Full Length Protein (L260F), Flag,His Tag (Detergent)

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GLP1R GLR-H82D3 Biotinylated Human GLP1R Full Length Protein, Flag Tag&His,Avitag™ (Detergent)

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GPRC5B GPB-H52D7 Human GPRC5B Protein, Flag,His Tag (Detergent)

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GPRC5D GPD-H82D5 Biotinylated Human GPRC5D Full Length Protein, Flag,His,Avitag™ (Detergent)

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GPRC5D GPD-H52D5 Human GPRC5D Full Length Protein, Flag,His Tag (Detergent)

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GPRC5D GPD-M52D3 Mouse GPRC5D Protein, Flag,His Tag (Detergent)

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GPRC5D GPD-C52D3 Cynomolgus GPRC5D Protein, Flag,His Tag (Detergent) (SPR verified)

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SLC2A1 SL1-H55H3 Human SLC2A1 Full Length Protein, His Tag (Detergent)

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- DC-11 200x DDM CHS buffer

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- DN-12 50x Digitonin buffer

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- LG-13 200x LMNG CHS buffer

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分子 货号 产品描述 订购/预购
CCR8 CC8-H52D7 Human CCR8 Protein, Flag,His Tag&Twin-Strep Tag (Nanodisc)

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GPRC5D GPD-H82D7 Biotinylated Human GPRC5D Full Length Protein, Flag,His,Avitag™ (Nanodisc)

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GPRC5D GPD-H52D6 Human GPRC5D Full Length Protein, Flag,His Tag (Nanodisc)

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GPRC5D GPD-C82D4 Cynomolgus GPRC5D Protein, Flag,His Tag (Nanodisc)

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MSP1D1 APC-HF1H3 FITC-Labeled Human MSP1D1 Protein, His Tag (Nanodisc)

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MSP1D1 APO-H51H3 Human MSP1D1 Protein, His Tag (Nanodisc)

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MSP1D1 APO-H81Q5 Biotinylated Human MSP1D1 Protein, His,Avitag™ (Nanodisc)

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我们还可提供相应稳定细胞株及细胞株开发服务，助力抗体药物开发及临床申报。欢迎咨询~
了解更多GPCRs相关信息

> 【前沿进展】屡次摘获诺贝尔奖，膜蛋白的能量超乎想象

> 【靶点聚焦】GPRC5D，治疗多发性骨髓瘤的下一个热门靶点

> 【靶点聚焦】七次跨膜蛋白CCR8：肿瘤治疗更有效更安全的靶点

> 【靶点聚焦】CXCR4，治疗艾滋病和癌症的“超能”靶点

> 【靶点聚焦】【靶点新势力】趋化因子受体CCR5，抗 HIV的优秀靶点

> 【靶点聚焦】ACRO“膜杰作”：全长七次跨膜蛋白SSTR2

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