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Cynomolgus CD79A Protein, His Tag

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分子别名(Synonym)

CD79A, CD79a, B-cell antigen receptor complex-associated protein alpha chain, B-cell antigen receptor complex-associated protein alpha chain, Ig-alpha, MB-1 membrane glycoprotein, Membrane-bound immunoglobulin-associated protein, Surface IgM-associated protein, CD_antigen: CD79a, IGA, MB1

表达区间及表达系统(Source)

Cynomolgus CD79A, His Tag (CDA-C52H3) is expressed from human 293 cells (HEK293). It contains AA Leu 33 - Arg 142 (Accession # XP_045235481.1).

Request for sequence

蛋白结构(Molecular Characterization)

CD79A Structure

This protein carries a polyhistidine tag at the C-terminus

The protein has a calculated MW of 14.4 kDa. The protein migrates as 27-35 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.

内毒素(Endotoxin)

Less than 1.0 EU per μg by the LAL method.

纯度(Purity)

>90% as determined by SDS-PAGE.

制剂(Formulation)

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4 with trehalose as protectant.

Contact us for customized product form or formulation.

重构方法(Reconstitution)

Please see Certificate of Analysis for specific instructions.

For best performance, we strongly recommend you to follow the reconstitution protocol provided in the CoA.

存储(Storage)

For long term storage, the product should be stored at lyophilized state at -20°C or lower.

Please avoid repeated freeze-thaw cycles.

This product is stable after storage at:

  1. -20°C to -70°C for 12 months in lyophilized state;
  2. -70°C for 3 months under sterile conditions after reconstitution.
 

电泳(SDS-PAGE)

CD79A SDS-PAGE

Cynomolgus CD79A, His Tag on SDS-PAGE under reducing (R) condition. The gel was stained with Coomassie Blue. The purity of the protein is greater than 90%.

背景(Background)

B-Cell Antigen Receptor Complex-Associated Protein Alpha Chain(CD79a), also known as CD79α, IgM-α, Ig-α and mb-1, which is a signaling component of the preB cell receptor (preBCR). Covalently linked CD79a and CD79b heterodimer constitutes the B cell antigen receptor (BCR) with membrane immunoglobulin (mIg) in a non-covalent association. CD79a is required in cooperation with CD79b for initiation of the signal transduction cascade activated by binding of antigen to the B-cell antigen receptor complex (BCR), leading to internalization of the complex, trafficking to late endosomes and antigen presentation. CD79a is also required for BCR surface expression and for efficient differentiation of pro- and pre-B-cells.

 

 

前沿进展

 
 
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CD79A靶点信息
英文全称:B-cell antigen receptor complex-associated protein alpha chain
中文全称:B细胞抗原受体复合体相关蛋白α链
种类:
上市药物数量:0详情
临床药物数量:1详情
最高研发阶段:临床二期
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